Related Experiment Video
Updated: May 28, 2025

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
Published on: October 20, 2023
Melatonin use in typically developing (TD) children: International Pediatric Sleep Association (IPSA) Expert
, Judith Owens1, Narong Simakajornboon2
1Department of Neurology, Pediatric Sleep Center, Boston Children's Hospital, Boston, MA, USA.
Insights
This study provides evidence-based recommendations for using melatonin to manage insomnia in children and adolescents. It addresses indications, dosage, and safety for healthcare practitioners.
Area of Science:
- Pediatric Sleep Medicine
- Pharmacology
Background:
- Melatonin is globally used for pediatric insomnia.
- Clinical guidelines for melatonin use in typically developing children are scarce.
Purpose of the Study:
- To develop evidence-based and consensus-based recommendations for melatonin use in pediatric insomnia.
- To guide healthcare practitioners in clinical decision-making.
Main Methods:
- Literature review by a task force of pediatric sleep experts.
- Development of consensus-based recommendations.
Main Results:
- Recommendations cover indications, timing, dosage, and safety of melatonin.
- Addresses use in pediatric clinical settings.
Conclusions:
- Provides guidance for melatonin use in pediatric insomnia.
- Aims to standardize and improve the safe application of melatonin in children.
Abstract:
Although melatonin is widely used globally for the management of insomnia in children and adolescents, there are few clinical guidelines available for healthcare practitioners, particularly in typically developing (TD) children. Because existing data are either sparse or inconclusive, a task force comprised of pediatric sleep researchers and clinicians was established by the International Pediatric Sleep Association (IPSA) to first examine the available literature and to then develop a set of evidence-based (when possible) and consensus-based recommendations to guide practitioners in decision-making regarding melatonin use in pediatric insomnia. The following recommendations regarding appropriate indications for melatonin in children, considerations regarding timing and dosage, safety issues and caveats in recommending use of melatonin in pediatric clinical settings, are presented as a companion to a Technical Report summarizing the available literature.
More Related Videos
Related Concept Videos
Management of Insomnia
Nightmares and Night Terrors
Nightmares...
Sedatives and Hypnotics Drugs: Miscellaneous Agents
Melatonin congeners like ramelteon (Rozerem) and tasimelteon (Hetlioz) selectively bind to melatonin receptors (MT1 and MT2) and thus mimic the actions of melatonin, a hormone that regulates sleep-wake cycles. Tasimelteon is primarily used for non-24-hour sleep-wake disorder, common in blind patients. They are also used to treat conditions like insomnia...
Understanding Sleep
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
Narcolepsy
Insomnia
Multiple factors contribute...

