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Updated: May 28, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

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De novo RUNX1-driven acute myeloid leukemia requiring integrative genetics

Celeste C Eno1, Jeremy Lorber2, Eric Vail1

  • 1Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.

Cancer Genetics
|February 9, 2025
PubMed
Summary

A RUNX1 deletion drove acute myeloid leukemia in a patient without prior myeloid neoplasm. Multiple tests were needed, revealing the adverse prognosis associated with RUNX1 deletion AML.

Keywords:
Acute myeloid leukemia, classificationCopy number variantFISHNext generation sequencingRUNX1 deletion

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