Related Experiment Video

Updated: May 28, 2025

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway
07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

338

Waldenström's Macroglobulinemia/Lymphoplasmacytic Lymphoma Developing Renal AA Amyloidosis: A Case Report and

Yusuke Ishizuka1, Yuji Oe1, Sosuke Kinomura1

  • 1Department of Nephrology, Tohoku University Graduate School of Medicine, Japan.

Internal Medicine (Tokyo, Japan)
|February 9, 2025
PubMed

Insights

AA amyloidosis, a rare kidney complication of Waldenström's macroglobulinemia, can recur even after treatment. This case shows challenges in managing recurrent amyloidosis and its fatal complications, including during COVID-19 infection.

Area of Science:

  • Nephrology
  • Hematology
  • Oncology

Background:

  • AA amyloidosis is a rare renal complication associated with Waldenström's macroglobulinemia/lymphoplasmacytic lymphoma (WM/LPL).
  • Monoclonal IgM-secreting diseases can present with diverse renal manifestations.
  • Management of AA amyloidosis in the context of other severe illnesses poses significant challenges.

Purpose of the Study:

  • To report a case of recurrent AA amyloidosis in a patient with WM/LPL.
  • To highlight the complexities in managing renal complications of WM/LPL.
  • To discuss the impact of COVID-19 on a patient with pre-existing WM/LPL and AA amyloidosis.

Main Methods:

  • Case report of a 66-year-old male patient with WM/LPL.
  • Renal biopsy to diagnose AA amyloidosis.
  • Chemotherapy for hematologic and nephrotic syndromes.
  • Monitoring during COVID-19 infection and subsequent renal biopsy.

Main Results:

  • Initial chemotherapy led to remission of hematologic and nephrotic syndromes.
  • Recurrence of AA amyloidosis with massive proteinuria was observed during COVID-19 infection.
  • Treatment with increased prednisolone was ineffective for proteinuria.
  • The patient died from cryptococcal meningitis.

Conclusions:

  • AA amyloidosis presents a diverse spectrum of renal involvement in monoclonal IgM-secreting diseases.
  • Managing fatal complications, especially during superimposed infections like COVID-19, is difficult.
  • This case underscores the need for vigilant monitoring and tailored management strategies for patients with WM/LPL and AA amyloidosis.
Keywords:
COVID-19monoclonal IgM-secreting diseasenephrotic syndromeprednisolone

More Related Videos

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice09:43

Analyses of Proteinuria, Renal Infiltration of Leukocytes, and Renal Deposition of Proteins in Lupus-prone MRL/lpr Mice

Published on: June 8, 2022

2.8K
Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells09:40

Isolation, Characterization, And High Throughput Extracellular Flux Analysis of Mouse Primary Renal Tubular Epithelial Cells

Published on: June 20, 2018

17.3K

Related Concept Videos

Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
9.2K
Renal Corpuscle01:20

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
1.6K
Lysosomal Hydrolases01:22

Lysosomal Hydrolases

Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.7K