Related Experiment Video
Updated: May 28, 2025

Electroporation-Based Genetic Modification of Primary Human Pigment Epithelial Cells Using the Sleeping Beauty Transposon System
Published on: February 4, 2021
The Frequency of Periorbital Hyperpigmentation Risk Factors
Fateme Heidari1, Mohammad Ebrahim Zadeh2, Maryam Haji Abole Zadeh3
1Department of Medicine, Yazd Branch, Islamic Azad University, Yazd, Iran.
Periorbital hyperpigmentation (POH) is a common cosmetic concern. Factors like family history, sun exposure, stress, and hormonal pills significantly impact POH severity, while sleep quality showed no significant association.
Area of Science:
- Dermatology
- Cosmetic Science
Background:
- Periorbital hyperpigmentation (POH) is a prevalent cosmetic concern globally, impacting emotional well-being.
- Limited research exists on the diverse factors contributing to POH, with some findings being contradictory.
Purpose of the Study:
- To investigate the precise influence of various risk factors on the severity of periorbital hyperpigmentation.
- To clarify the association between demographic data, lifestyle habits, underlying diseases, and POH severity.
Main Methods:
- A cross-sectional study involving 116 patients in an Iranian dermatology outpatient department.
- Patients were classified into mild, moderate, severe, and very severe POH categories based on physical examination.
- Data on demographics, habits, and underlying diseases were collected via questionnaires, analyzed using chi-square and linear regression tests.
Main Results:
- Positive family history, stress, prolonged sun/television exposure, and hormonal pill usage were significantly associated with POH.
- Sleep quality did not show a significant relationship with POH severity.
- A correlation between POH and certain underlying diseases was identified.
Conclusions:
- Periorbital hyperpigmentation is an undesirable condition influenced by multiple factors.
- Key contributing factors identified include eye rubbing and prolonged television viewing.
- The study confirmed the impact of family history, sun exposure, and stress, while questioning the role of sleep quality and atopy in POH.
More Related Videos
12:37Pharmacologic Induction of Epidermal Melanin and Protection Against Sunburn in a Humanized Mouse Model
Published on: September 7, 2013
10:39Author Spotlight: Improved Lipofuscin Models and Quantification of Outer Segment Phagocytosis Capacity in Highly Polarized Human Retinal Pigment Epithelial Cultures
Published on: April 14, 2023
Related Concept Videos
Pigmentation
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Photoreceptors and Visual Pathways
Changes in Skin Color: Clinical Perspectives
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Accessory Structures of the Eye
Genetic Lingo