Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

101
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
101
Peptic Ulcer Disease V: Surgical Management and Nursing Care01:25

Peptic Ulcer Disease V: Surgical Management and Nursing Care

199
Surgical management and nursing care are crucial in treating Peptic Ulcer Disease (PUD). Here is an organized and enhanced overview of the surgical interventions and the associated nursing care for PUD:
Surgical Interventions for Peptic Ulcer Disease
199
Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy01:26

Endoscopic Procedures IV: Sigmoidoscopy and Laproscopy

39
Sigmoidoscopy and laparoscopy are distinct medical procedures that enable physicians to internally inspect different parts of the GI tract. Although they serve different purposes, each is essential for diagnosing and, in some cases, treating various medical conditions.
Sigmoidoscopy
Sigmoidoscopy is a diagnostic procedure that uses a flexible sigmoidoscope equipped with a light source and camera to examine the rectum and sigmoid colon. The procedure involves inserting the tube through the anus...
39
Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

59
Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
59
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

3.9K
Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Availability and Use of Social Determinants of Health Data in Alliance Gastrointestinal Cancer Clinical Trials.

JCO oncology practice·2026
Same author

ypTNM versus pTNM staging after neoadjuvant therapy in rectal cancer.

Journal of the National Cancer Institute·2026
Same author

Impact of Dedicated Care Coordination on Access to Multidimensional Support Services in Young-Onset Colorectal Cancer: A Pragmatic Trial.

JCO oncology practice·2026
Same author

Association of social determinants of health diagnosis codes with overall survival in Medicare-insured patients with cancer.

Journal of the National Cancer Institute·2026
Same author

Comparison of surgical outcomes of robotic complete mesocolic excision for right-sided colon cancer in obese versus non-obese patients.

Surgical endoscopy·2026
Same author

Can Patients With Recurrent or Primary Squamous Cell Carcinoma of the Anus in a Previously Irradiated Pelvis Receive Definitive Reirradiation?

Advances in radiation oncology·2026

Related Experiment Video

Updated: May 28, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

204

Risk Factors for Regrowth After Nonoperative Management for Rectal Cancer.

Neal Bhutiani1, Kentaro Ochiai1, Oliver Peacock1

  • 1Department of Colon and Rectal Surgery, University of Texas MD Anderson Cancer Center, Houston, TX, USA.

Annals of Surgical Oncology
|February 9, 2025
PubMed
Summary

For rectal cancer patients achieving complete response after neoadjuvant therapy, high-risk MRI features like extramural vascular invasion and positive pelvic sidewall nodes predict tumor regrowth. Careful consideration of nonoperative management is advised.

Keywords:
Neoadjuvant therapyNonoperative managementRectal cancerRegrowthWatch and wait

More Related Videos

Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

16.4K
Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

5.5K

Related Experiment Videos

Last Updated: May 28, 2025

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
06:46

Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery

Published on: September 27, 2024

204
Murine Ileocolic Bowel Resection with Primary Anastomosis
08:49

Murine Ileocolic Bowel Resection with Primary Anastomosis

Published on: October 29, 2014

16.4K
Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer
12:45

Robot-assisted Total Mesorectal Excision and Lateral Pelvic Lymph Node Dissection for Locally Advanced Middle-low Rectal Cancer

Published on: February 12, 2022

5.5K

Area of Science:

  • Oncology
  • Gastroenterology
  • Surgical Oncology

Background:

  • Rectal cancer patients achieving complete clinical response (cCR) after neoadjuvant therapy may undergo nonoperative management (NOM).
  • A subset of these patients experience tumor regrowth, necessitating salvage surgery.
  • Identifying factors predicting regrowth is crucial for optimizing NOM patient selection.

Purpose of the Study:

  • To identify clinicopathologic factors associated with tumor regrowth in rectal cancer patients managed nonoperatively after neoadjuvant therapy.
  • To improve patient selection for nonoperative management (NOM) by predicting regrowth risk.

Main Methods:

  • Retrospective analysis of rectal cancer patients at a single NCI-designated Comprehensive Cancer Center who underwent NOM based on cCR or near-cCR.
  • Stratification of patients based on the occurrence of tumor regrowth during follow-up.
  • Comparison of tumor and treatment details to identify factors influencing regrowth-free survival (RFS).

Main Results:

  • Among 125 patients, 20.8% experienced local regrowth and 6.4% had distant metastasis.
  • Extramural vascular invasion (EMVI) and clinically positive pelvic sidewall lymph nodes (PSW) were significantly associated with worse RFS (HR 2.48, p=0.03; HR 2.77, p=0.002).
  • Patients with near-cCR at first endoscopic evaluation trended towards higher RFS (HR 2.12, p=0.07) and showed a significant difference in 1-year regrowth (HR 5.58, p=0.03).

Conclusions:

  • High-risk MRI features, specifically EMVI and positive PSW nodes, predict tumor regrowth in rectal cancer patients with clinical response.
  • Near-complete endoscopic response may also indicate a higher risk of subsequent tumor regrowth.
  • The decision to pursue NOM requires careful consideration of the elevated risk of tumor regrowth in patients with these high-risk features.