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Related Concept Videos

Proteomics01:33

Proteomics

7.2K
A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term...
7.2K
MALDI-TOF Mass Spectrometry01:19

MALDI-TOF Mass Spectrometry

4.7K
Mass spectrometry is a powerful characterization technique that can identify and separate a wide variety of compounds ranging from chemical to biological entities, based on their mass-to-charge ratio (m/z). The instruments that allow this detection, known as mass spectrometers, have three components: an ion source, a mass analyzer, and a detector. These spectrometers differ based on the nature of their ion source and analyzers.
Matrix-assisted laser desorption ionization (MALDI) is a commonly...
4.7K

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Updated: May 28, 2025

Deep Proteome Profiling by Isobaric Labeling, Extensive Liquid Chromatography, Mass Spectrometry, and Software-assisted Quantification
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Clinical Proteomics, Quo Vadis?

Harald Mischak1, Joost P Schanstra2,3, Antonia Vlahou4

  • 1Mosaiques Diagnostics GmbH, Hannover, Germany.

Proteomics
|February 10, 2025
PubMed
Summary
This summary is machine-generated.

Clinical proteomics has published extensively, but clinical applications remain limited. Future success requires focusing on patient benefit and treatment impact, not just publication counts.

Keywords:
clinical proteomicsclinical studyimplementationpatient benefit

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Area of Science:

  • Biomedical research
  • Translational medicine
  • Proteomics

Background:

  • Clinical proteomics has experienced substantial growth over 20 years, evidenced by over 40,000 publications.
  • Despite extensive research, the translation of clinical proteomics findings into practical patient care remains limited.

Purpose of the Study:

  • To discuss key challenges hindering clinical proteomics' application.
  • To propose solutions for improving the field's translational success and patient impact.

Main Methods:

  • This viewpoint article analyzes the current state of clinical proteomics.
  • It identifies barriers to clinical implementation and suggests strategic directions.

Main Results:

  • The number of publications does not equate to clinical success.
  • A shift in focus towards patient management and treatment outcomes is crucial.

Conclusions:

  • Clinical proteomics must prioritize demonstrable patient benefit to achieve its promise.
  • Future efforts should concentrate on translating research into tangible improvements in patient care and management.