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Related Experiment Video

Updated: May 28, 2025

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

Published on: March 1, 2015

Association Between Cognitive Impairment and Dysphagia: A Two-Sample Mendelian Randomization Study.

Yueqin Tian¹, Jiahui Hu², Qianqian Wang²

¹Department of Rehabilitation Medicine, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

Brain and Behavior

|February 10, 2025

Summary

This study found a causal link between cognitive impairment and dysphagia using genetic data. Individuals with cognitive issues need clinical attention to prevent swallowing difficulties.

Keywords:

Mendelian randomization causality cognitive impairment dysphagia

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Last Updated: May 28, 2025

Adapting Human Videofluoroscopic Swallow Study Methods to Detect and Characterize Dysphagia in Murine Disease Models

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Published on: March 1, 2015

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

Coordinate Mapping of Hyolaryngeal Mechanics in Swallowing

Coordinate Mapping of Hyolaryngeal Mechanics in Swallowing

Published on: May 6, 2014

Area of Science:

Genetics
Neurology
Gastroenterology

Background:

Observational studies show mixed results on the link between cognitive impairment and dysphagia.
Previous studies may be limited by small sample sizes and confounding factors.

Purpose of the Study:

To genetically investigate the causal relationship between cognitive impairment and dysphagia.
To address inconsistencies in previous observational findings.

Main Methods:

Utilized Mendelian randomization (MR) analysis.
Included large genome-wide association studies (GWAS) meta-analysis for cognitive impairment (269,867 individuals) and dysphagia (165,765 individuals).
Employed five MR methods (IVW, MR-Egger, MR-RAPS, weighted median, weighted mean) and sensitivity analyses for heterogeneity and pleiotropy.

Main Results:

A significant causal association was found between cognitive impairment and an increased risk of dysphagia (IVW OR: 1.206, p=0.00508).
Results were consistent across multiple MR methods (weighted median, weighted mode, MR-RAPS).
Sensitivity analyses confirmed no significant heterogeneity or horizontal pleiotropy, indicating reliable findings.

Conclusions:

Mendelian randomization analysis provides genetic evidence for a causal effect of cognitive impairment on dysphagia.
Clinical attention for individuals with cognitive impairment is recommended to prevent dysphagia development.