Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Spectrophotometry: Introduction01:16

Spectrophotometry: Introduction

Spectrophotometry is the quantitative measurement of the absorption, reflection, diffraction, or transmission of electromagnetic radiation through a material as a function of the intensity and wavelength of the radiation. A spectrophotometer is a device used to measure the change in the radiation intensity caused by its interaction with the material.
The essential components of a spectrophotometer include a source of electromagnetic radiation, a slot for placing a material to be analyzed, and a...
UV–Vis Spectrometers01:14

UV–Vis Spectrometers

The absorbance of UV and visible (UV–visible) radiations is measured using a UV–visible spectrophotometer. Deuterium lamps, which emit UV radiation, and tungsten lamps, which produce radiation in the visible region, are used as light sources in UV–visible spectrophotometers. A monochromator or prism is used for diffraction grating, i.e., to split the incoming radiation into different wavelengths. A system of slits is used to focus the desired wavelength on the sample cell. Samples for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Feasibility evaluation of tumor treating fields for brainstem gliomas.

Journal of neuro-oncology·2026
Same author

A multi-modal flow phantom for quantitative PET/Spectral CT.

bioRxiv : the preprint server for biology·2026
Same author

<i>Radiology: Cardiothoracic Imaging</i> Highlights 2025.

Radiology. Cardiothoracic imaging·2026
Same author

Medical 3-D Printing Within a Health Care Facility.

Journal of the American College of Radiology : JACR·2026
Same author

Quantitative imaging of the central lymphatic system with spectral CT iodine mapping: a feasibility study in swine.

medRxiv : the preprint server for health sciences·2026
Same author

Efficient and Practical Framework for Bias Estimation in Spectral CT.

medRxiv : the preprint server for health sciences·2026

Related Experiment Video

Updated: Jul 7, 2026

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
07:51

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

Published on: January 12, 2019

6.7K

Spectral quantification in different lumen diameters for cardiovascular applications.

Leening P Liu1,2, Martin V Rybertt1, Pouyan Pasyar1

  • 1Department of Radiology, Perelman School of Medicine, Philadelphia, PA, USA.

Conference Proceedings. International Conference on Image Formation in X-Ray Computed Tomography
|February 10, 2025
PubMed
Summary

Photon-counting CT (PCCT) offers high spatial resolution for cardiovascular imaging. This study found PCCT spectral quantification is accurate for coronary artery phantoms larger than 6 mm, but less reliable for smaller vessels.

Keywords:
Cardiac CTIodine QuantificationPhoton-counting CTSpectral CT

More Related Videos

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts
08:51

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts

Published on: May 12, 2019

6.7K
Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
12:54

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

3.2K

Related Experiment Videos

Last Updated: Jul 7, 2026

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva
07:51

A Novel Approach to Monitoring Graft Neovascularization in the Human Gingiva

Published on: January 12, 2019

6.7K
Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts
08:51

Intra-cardiac Side-Firing Light Catheter for Monitoring Cellular Metabolism using Transmural Absorbance Spectroscopy of Perfused Mammalian Hearts

Published on: May 12, 2019

6.7K
Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo
12:54

Simultaneous Brightfield, Fluorescence, and Optical Coherence Tomographic Imaging of Contracting Cardiac Trabeculae Ex Vivo

Published on: October 2, 2021

3.2K

Area of Science:

  • Medical Imaging
  • Radiology
  • Biomedical Engineering

Background:

  • Dual-source photon-counting CT (PCCT) combines high spatial resolution and spectral imaging, beneficial for visualizing small vessels like coronary arteries.
  • Previous studies confirmed PCCT's high spatial resolution and quantification accuracy, but the impact of lumen size on spectral quantification remained unevaluated.

Purpose of the Study:

  • To evaluate the effect of lumen size on spectral quantification accuracy in dual-source photon-counting CT.
  • To assess how varying phantom sizes, iodine concentrations, and radiation doses influence spectral quantification in PCCT.

Main Methods:

  • Phantoms with internal diameters from 4 to 12 mm were created to simulate coronary arteries.
  • Phantoms were filled with iodine solutions (2, 5, 10 mg/mL) and scanned using PCCT.
  • Virtual monoenergetic images (VMI) at 70 keV, iodine density maps, and virtual non-contrast (VNC) maps were analyzed.

Main Results:

  • Consistent spectral quantification was achieved for lumen diameters greater than 6 mm across all phantom sizes.
  • VMI 70 keV showed minimal deviation (±15, ±12, ±4) at larger diameters (12 mm) for different iodine concentrations.
  • Significant deviations in VMI 70 keV, iodine density maps, and VNC were observed at a 4 mm lumen diameter, particularly with larger phantoms.

Conclusions:

  • Dual-source photon-counting CT demonstrates reliable spectral quantification for coronary artery phantoms with lumen diameters exceeding 6 mm.
  • The high spatial resolution and quantification accuracy of PCCT show synergy, supporting the use of quantitative metrics in cardiac imaging.
  • Further development of quantitative applications in diagnostic cardiac imaging is anticipated due to these findings.