Related Experiment Video

Updated: May 28, 2025

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
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Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

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Comparative Analysis of Adverse Drug Reactions Associated with Fluoroquinolones and Other Antibiotics: A

Hanan Alshareef1, Khalidah A Alenzi2, Budor R Albalawi3

  • 1Pharmacy Practice Department, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.

Drug, Healthcare and Patient Safety
|February 10, 2025
PubMed
Abstract

Insights

Fluoroquinolones (FQs) cause the most reported antibiotic adverse drug reactions (ADRs), particularly neurological events in patients over 40. Regular safety assessments are vital for appropriate antibiotic use.

Area of Science:

  • Pharmacovigilance
  • Drug Safety
  • Antimicrobial Therapy

Background:

  • Fluoroquinolones (FQs) are widely used antimicrobials with known safety concerns.
  • Adverse drug reactions (ADRs) associated with FQs require thorough investigation.
  • This study focuses on FQ ADRs reported in a regional database.

Purpose of the Study:

  • To assess the incidence, severity, and types of FQ-related ADRs.
  • To compare FQ ADRs with those of other antibiotics.
  • To identify patient demographics and outcomes associated with FQ ADRs.

Main Methods:

  • Retrospective cross-sectional observational study.
  • Analysis of ADR reports submitted to a Regional Pharmacovigilance Center (PVC) database (January 2019 - December 2022).
  • Data extraction using Saudi ADR forms, consistent with FDA's MedWatch.

Main Results:

  • Fluoroquinolones accounted for the highest proportion of reported antibiotic ADRs (29.3%).
  • FQ-related ADRs were more common in individuals over 40 years old.
  • Neurological adverse events were significantly more likely in patients receiving FQs (OR 4.15).
  • Most FQ ADRs were of moderate severity and resolved after medical intervention.

Conclusions:

  • The fluoroquinolone class shows a higher incidence of ADRs compared to other antibiotics.
  • Continuous safety monitoring of antibiotics is essential.
  • Promoting awareness and judicious use of FQs for infections unresponsive to alternatives is recommended.
Keywords:
adverse drug reactions (ADRs)antibiotics (ABs)fluoroquinolones (FQs)pharmacovigilance

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