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Updated: May 28, 2025

Identification of Circular RNAs using RNA Sequencing
08:25

Identification of Circular RNAs using RNA Sequencing

Published on: November 14, 2019

12.1K

Research progress of circular RNA FOXO3 in diseases (review)

Min Zhao1,2, Minting Lin1,2, Zhibo Zhang3

  • 1Good Clinical Practice(GCP) Institutional Office of The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, China.

Global Medical Genetics
|February 10, 2025
PubMed

Insights

Circular RNA FOXO3 (circFOXO3) plays a key role in various diseases. This review systematically examines circFOXO3

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • Circular RNAs (circRNAs) are novel non-coding RNAs with regulatory roles.
  • circFOXO3, derived from the FOXO3 gene, is widely expressed in the cytoplasm.
  • circFOXO3 has been linked to diseases including cancer, cardiovascular, and neurological disorders.

Purpose of the Study:

  • To systematically review the latest research on circFOXO3 in human diseases.
  • To elucidate the biological functions and molecular mechanisms of circFOXO3.
  • To discuss future research directions and challenges in the field of circRNAs.

Main Methods:

  • Systematic literature review.
  • Analysis of recent research findings on circFOXO3.
  • Synthesis of information on biological functions and disease associations.

Main Results:

  • circFOXO3 exhibits specific expression patterns in different tissues and cells.
  • Emerging evidence links circFOXO3 to diverse pathological conditions.
  • The molecular mechanisms underlying circFOXO3's functions are being actively investigated.

Conclusions:

  • A comprehensive understanding of circFOXO3's role in disease is crucial.
  • Further research is needed to fully explore its therapeutic potential.
  • This review provides valuable insights for future circRNA studies.
Keywords:
BiomarkersCircFOXO3, circRNAsDisease pathogenesisMiRNA sponge

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