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Impact of Different Metabolic Indicators on Ventricular Repolarization Indices in Obese Children: A Case Control

Asmaa A El Sehmawy1, Rasha Abd El Samad Fawaz1, Nadia Ahmed Agiba2

  • 1Pediatrics Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.

Clinical Medicine Insights. Endocrinology and Diabetes
|February 10, 2025
PubMed

Insights

Obese children show prolonged ventricular repolarization, indicated by increased JTc and QTc dispersion, linked to higher BMI and insulin resistance.

Area of Science:

  • Pediatric Cardiology
  • Metabolic Disorders
  • Electrophysiology

Background:

  • Obesity, insulin resistance, and dyslipidemia are potential factors affecting ventricular repolarization in children.
  • Understanding these impacts is crucial for pediatric cardiovascular health.

Purpose of the Study:

  • To investigate the relationship between metabolic indicators and ventricular repolarization in obese children compared to healthy controls.
  • To identify specific ECG parameters affected by obesity and metabolic dysfunction in pediatric populations.

Main Methods:

  • A case-control study involving 90 children (45 obese, 45 normal weight).
  • Analysis of 12-lead electrocardiograms (ECGs) for corrected QT (QTc), QTc dispersion (QTcd), JTc dispersion, and TpTe interval.
  • Assessment of lipid profiles, fasting plasma glucose (FPG), and serum insulin to calculate Homeostatic Model Assessment of Insulin Resistance (HOMA-IR).

Main Results:

  • Obese children exhibited significantly higher triglycerides, cholesterol, LDL, fasting insulin, and HOMA-IR.
  • Obese children showed significantly longer QTcd and JTcd intervals.
  • Positive correlations were found between QTcd/JTc dispersion and waist circumference, BMI, blood pressure, fasting insulin, HOMA-IR, and LDL.

Conclusions:

  • Obese children demonstrate increased JTc and QTc dispersion, correlating with waist circumference, BMI, and insulin resistance.
  • Ventricular repolarization abnormalities in obese children are linked to metabolic dysregulation.
Abstract

Keywords:
ChildrenECGJT dispersionQT dispersionobesity

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