Risk factors for perioperative cerebral infarction in moyamoya disease: a meta-analysis
Jincan Wu1,2, Shiju Li2, Ruixin Liang1,2
1Fujian University of Traditional Chinese Medicine, Fujian, China.
Background:
The present study explored the risk factors for cerebral infarction perioperative moyamoya disease by meta-analysis.
Methods:
The PubMed, Embase, Cochrane library, Web of science databases were searched for case-control/cohort studies on risk factors for the emergence of cerebral infarction perioperative moyamoya disease, the search was done from the database creation to June 1, 2024, and the data was analyzed by using stata15.0.
Result:
Ten retrospective cohort studies (N = 3,239) were included. Meta-analysis results suggested posterior cerebral artery involvement [OR = 2.62, 95%CI (1.36, 5.06)], preoperative magnetic resonance angiography [OR = 2.81, 95%CI (1.27, 6.22)], previous infarction [OR = 2.52, 95% CI (1.69, 3.75)] were risk factor for the development of cerebral infarction perioperative moyamoya disease.
Conclusion:
This study proves that posterior cerebral artery involvement and grade of preoperative magnetic resonance angiography is higher, and the previous infarction happened moyamoya disease a risk factor for cerebral infarction. Therefore, people with these risk factors should be intervened in advance to prevent the occurrence of perioperative cerebral infarction.
Insights
Posterior cerebral artery involvement, higher grade preoperative magnetic resonance angiography, and prior infarction are key risk factors for perioperative cerebral infarction in moyamoya disease patients. Early intervention for individuals with these factors is crucial for prevention.
Area of Science:
- Neurology
- Vascular Surgery
- Radiology
Background:
- Moyamoya disease is a rare cerebrovascular disorder characterized by progressive stenosis of the internal carotid arteries.
- Perioperative cerebral infarction is a significant complication, leading to increased morbidity and mortality.
- Identifying risk factors for perioperative cerebral infarction is crucial for improving patient outcomes.
Purpose of the Study:
- To conduct a meta-analysis to identify significant risk factors for perioperative cerebral infarction in patients with moyamoya disease.
- To provide evidence-based recommendations for risk stratification and preventative strategies.
Main Methods:
- A systematic search of PubMed, Embase, Cochrane Library, and Web of Science databases was performed up to June 1, 2024.
- Included ten retrospective cohort studies with a total of 3,239 patients.
- Data analysis was conducted using Stata 15.0.
Main Results:
- Posterior cerebral artery involvement was identified as a significant risk factor (OR = 2.62, 95% CI [1.36, 5.06]).
- Higher grade of preoperative magnetic resonance angiography was also a significant risk factor (OR = 2.81, 95% CI [1.27, 6.22]).
- A history of previous infarction was a notable risk factor (OR = 2.52, 95% CI [1.69, 3.75]).
Conclusions:
- Posterior cerebral artery involvement, advanced preoperative magnetic resonance angiography findings, and prior infarction are confirmed risk factors for perioperative cerebral infarction in moyamoya disease.
- Proactive intervention for patients presenting with these risk factors is recommended to mitigate the risk of perioperative cerebral infarction.
