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Changes in adenylate energy charge and total adenine nucleotide concentration in mouse testis induced by cadmium
Toxicology Letters
|April 1, 1985
Abstract:
Subcutaneous administration of CdCl2 (3 mg/kg body weight) caused a decrease in adenylate energy charge, (ATP + 0.5ADP)/(ATP + ADP + AMP), and a depletion of the adenine nucleotide pool in the testis of mice. This preceded a decrease in LDH-X activity in the testicular extracts. These results biochemically support the hypothesis that the testicular damage induced by cadmium is secondary to anoxia caused by vascular lesion.