Related Experiment Video
Updated: May 28, 2025

Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
Comprehensive Analysis of Intermittent Fasting on Anthropometric Indices, Glycemic Control, and Serum Insulin Levels
Aparnna Unnikrishnan Nair1, Naveenkumar Nallathambi2, S Yogesh2
1Department of Internal Medicine, Altnagelvin Area Hospital, Western Health and Social Care Trust, Londonderry, UK.
Background:
Type 2 diabetes significantly impacts socioeconomic conditions, with periods of obesity and insulin resistance preceding diagnosis. Fasting, practiced for millennia, offers the potential to manage and possibly reverse diabetes. This study aims to assess the effects of intermittent fasting on various health indicators in obese type 2 diabetic patients.
Methodology:
Thirty obese volunteers with type 2 diabetes mellitus, uncontrolled by metformin alone, aged 20-60, were included. They followed a 16:8 intermittent fasting regimen for four weeks. Initial and postintervention measurements included height, weight, BMI, waist-hip ratio, waist circumference, fasting blood sugar, and serum insulin. Results were compared using the student t-test.
Results:
After four weeks, significant reductions were observed in anthropometric indices and fasting blood sugar, but no change in serum insulin levels.
Conclusion:
A 16:8 intermittent fasting regimen significantly reduced fasting blood glucose levels and anthropometric indices in obese type 2 diabetes patients over four weeks, with no effect on serum insulin levels. Larger and longer-term studies are needed to explore long-term effects and mechanisms.
More Related Videos
08:30Intraperitoneal Glucose Tolerance Test, Measurement of Lung Function, and Fixation of the Lung to Study the Impact of Obesity and Impaired Metabolism on Pulmonary Outcomes
Published on: March 15, 2018
08:13Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
Published on: January 7, 2018
Related Concept Videos
Diabetes: Symptoms, Diagnosis, and Complications
Diabetes Mellitus: Type 2 and Gestational
Carbohydrate Metabolism
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
Diabetes: Management and Pharmacotherapy
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
Insulin: Dosing Regimen and Adverse Effects
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Metabolic States of the Body: Fasting and Starvation