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Correlation Between the Use of Vesicant Medications and The Incidence of Phlebitis in Pediatric Ward
Lily Annisa1, Suci Hanifah1, Putri Setiani2
1Department of Pharmacy, Islamic University of Indonesia, Indonesia.
Insights
Vesicant medications are linked to phlebitis in pediatric patients. This study found vesicant use significantly increases the risk of phlebitis in young inpatients.
Area of Science:
- Pediatric Nursing
- Vascular Access
- Pharmacology
Background:
- Phlebitis involves inflammation of venous endothelial cells.
- Vesicant medications are a known cause of phlebitis, particularly in children.
Purpose of the Study:
- To examine the relationship between vesicant medication use and phlebitis occurrence.
- To identify risk factors for phlebitis in pediatric inpatients.
Main Methods:
- Descriptive observational study conducted in a pediatric ward (June-July 2022).
- Included pediatric inpatients (1 month-18 years) receiving IV infusions >24 hours.
- Data analyzed using bivariate and multivariate correlation analyses.
Main Results:
- 27.6% of 174 patients developed phlebitis; 37.9% received vesicants.
- Gentamicin was the most common vesicant (74.24%).
- Vesicant use (RR: 4.17) and >3 IV drugs (RR: 2.6) were significantly associated with phlebitis. Multivariate analysis confirmed vesicants as a risk factor (OR: 4.41).
Conclusions:
- Vesicant medication administration is a significant risk factor for phlebitis in pediatric inpatients.
- Implementing preventative measures for vesicant administration is crucial in pediatric care settings.
Background:
Phlebitis is an inflammatory process that is characterized by inflamed venous endothelial cells. Vesicant medications are found to be one of the causes of phlebitis, especially in pediatric patients.
Objective:
To investigate the correlation between the use of vesicant medications and phlebitis incidence.
Material And Methods:
The study was descriptive observational conducted over the period of June-July 2022 in a pediatric ward. The inclusion criteria were male or female pediatric inpatients, aged 1 month-18 years, and receiving medication via intravenous infusion for >24 hours. The data obtained were then analyzed for correlations by using bivariate and multivariate analysis.
Results And Conclusion:
A total of 174 patients met the inclusion criteria; 27.6% experienced phlebitis, and 37.9% received vesicant medications. The most frequently used vesicant medications in the pediatric ward was gentamicin (74.24%). The use of vesicants and administration of >3 intravenous drugs showed statistically significant results associated with the incidence of phlebitis, with RR: 4.17 (P < 0.001; CI = 2.1-8.3) and RR = 2.6 (P = 0.012; CI = 1.2-5.5), respectively. The multivariate test results showed that the use of vesicants was a risk factor for phlebitis, with OR = 4.41 (P < 0.001; CI = 2.0-9.7). The use of vesicants is associated with the incidence of phlebitis in a pediatric inpatient ward.
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