Related Experiment Video
Updated: May 28, 2025

Novel Protocol for Generating Physiologic Immunogenic Dendritic Cells
Published on: May 17, 2019
Phototherapy in lymphoproliferative and inflammatory diseases associated with human T-lymphotropic virus
Brena Andrade de Lima Lobato1,2,3, João Augusto Gomes de Souza Monteiro de Brito2,3,4, José Maria de Castro Abreu Junior5
1Universidade Federal do Pará, Núcleo de Medicina Tropical, Postgraduate Program in Tropical Diseases, Belém, Pará, 66055-240, Brazil.
Background:
Dermatological manifestations affect 5% of patients with human T-lymphotropic virus (HTLV).
Methods:
Thirteen patients with inflammatory or lymphoproliferative dermatological diseases, both HTLV-positive and HTLV-negative, were selected for treatment with ultraviolet B narrowband (UVB-NB) phototherapy. Clinical and histopathological evaluations were conducted before and after 120 d of phototherapy.
Results:
All seven HTLV-positive patients evaluated were type 1. Clinical evaluation showed improvement in all 13 patients. In the histopathological examination, all patients with lymphoproliferative diseases and five with inflammatory diseases showed regression in most of the assessed parameters.
Conclusions:
The present research suggests that UVB-NB phototherapy is a promising treatment for lymphoproliferative and inflammatory skin diseases in HTLV-1 patients.
Related Concept Videos
Pulmonary Tuberculosis IV
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Tumor Immunotherapy
Pulmonary Tuberculosis I
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...

