Related Experiment Video

Updated: May 28, 2025

Isolation of Human Islets from Partially Pancreatectomized Patients
11:10

Isolation of Human Islets from Partially Pancreatectomized Patients

Published on: July 30, 2011

16.0K

From Acute Pancreatitis to Diabetes: Risk Factors and Timeline Analysis in a Pediatric Population Study

Michelle Saad, Lindsey Hornung1, Maisam Abu-El-Haija

  • 1Division of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.

Pancreas
|February 10, 2025
PubMed

Insights

Children developing diabetes mellitus after acute pancreatitis (AP) face longer hospital stays and more complications. Early screening and follow-up are crucial for managing postpancreatitis diabetes mellitus (PPDM) risks.

Area of Science:

  • Pediatric Endocrinology
  • Gastroenterology
  • Metabolic Disorders

Background:

  • Acute pancreatitis (AP) is a serious condition in children.
  • The long-term metabolic consequences of AP, particularly diabetes mellitus, are not well understood.
  • Identifying risk factors for postpancreatitis diabetes mellitus (PPDM) is essential for proactive management.

Purpose of the Study:

  • To determine the risk profile for PPDM in pediatric patients following a single AP episode.
  • To examine the relationship between AP severity and associated complications, length of stay (LOS), and intensive care unit (ICU) requirements.
  • To investigate the incidence and timing of PPDM development post-AP.

Main Methods:

  • Cross-sectional study utilizing the Pediatric Health Information System database (2011-2020).
  • Inclusion of patients ≤19 years old with index AP admissions, excluding those with prior diabetes mellitus (DM) or pancreatic surgery.
  • Diabetes mellitus (DM) diagnosis query performed for the period 2012-2021.

Main Results:

  • Out of 12,822 pediatric AP patients, 5.4% developed PPDM (320 during admission, 366 later).
  • PPDM onset occurred at a median of 1.9 months post-AP, with a wide range (IQR: 0-20.8 months).
  • PPDM patients exhibited longer LOS, increased ICU needs, sepsis, pancreatic necrosis, cyst formation, organ dysfunction, and comorbidities.

Conclusions:

  • Children are at risk for developing diabetes mellitus during or after acute pancreatitis.
  • Close outpatient follow-up and enhanced diabetes screening within 3-6 months post-discharge are recommended.
  • Early identification and management of PPDM can mitigate associated complications and improve patient outcomes.
Abstract

More Related Videos

Staining Protocols for Human Pancreatic Islets07:48

Staining Protocols for Human Pancreatic Islets

Published on: May 23, 2012

26.8K
Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice06:35

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice

Published on: June 28, 2021

3.9K

Related Concept Videos

Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
64
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
324
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
84
Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
60
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
848
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
499