Pancreatic Cystic Lesions in Children: A Comprehensive Scoping Review

Jacob A Mark1, Yuhua Zheng2, Salvador Rodriguez Franco3

  • 1From the Digestive Health Institute, University of Colorado School of Medicine, Children's Hospital Colorado, Aurora, CO.

Pancreas
|February 10, 2025
PubMed

Insights

Pediatric pancreatic cystic lesions (PPCLs) are rare and distinct from adult types. This review provides evidence-based guidelines for evaluating and managing these uncommon pediatric conditions.

Area of Science:

  • Gastroenterology
  • Pediatric Surgery
  • Oncology

Background:

  • Pediatric pancreatic cystic lesions (PPCLs) are uncommon and poorly understood, differing significantly from adult counterparts.
  • Limited literature exists on the etiology, evaluation, and management of PPCLs.
  • A multidisciplinary working group convened to address this knowledge gap.

Approach:

  • A scoping review was conducted, combining a targeted literature review for PPCL description and a systematic review for management recommendations.
  • The systematic review involved a two-stage screening process: title/abstract review followed by full-text assessment.
  • This approach ensured a comprehensive analysis of existing evidence.

Key Points:

  • 131 studies were included in the systematic review, with an additional 20 in the targeted search.
  • Five neoplastic and 10 nonneoplastic PPCL types were identified, with varying prevalence in children versus adults.
  • Evidence-based recommendations and management algorithms for PPCLs are presented.

Conclusions:

  • This work offers a comprehensive review and evidence-based management strategies for pediatric pancreatic cystic lesions.
  • It highlights areas where current literature is insufficient, emphasizing the need for further research.
  • Management algorithms are provided to guide clinical decision-making for PPCLs.
Abstract