Related Experiment Video
Updated: May 28, 2025
08:05
Occlusion of the Great and Small Saphenous Vein Using Copolymeric Glue Based on N-Butyl Cyanoacrylate and Methacryloxy Sulfolane
Published on: December 9, 2022
3.9K
Venous ulcers in Behçet syndrome.
Alican Karakoc1, Yesim Ozguler1, Ayse Ozdede1
1Division of Rheumatology, Department of Internal Medicine, Cerrahpaşa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Seminars in Arthritis and Rheumatism
|February 10, 2025
Summary
Stasis ulcers are a challenging complication of deep vein thrombosis in Behçet's syndrome, often recurring despite intensive treatment. Further research is needed to improve outcomes for these challenging venous ulcers.
Area of Science:
- Vascular Medicine
- Rheumatology
- Dermatology
Background:
- Post-thrombotic syndrome (PTS) and stasis ulcers are late complications of deep vein thrombosis (DVT) in Behçet's syndrome (BS).
- These ulcers represent a significant unmet medical need, impacting patient quality of life.
Purpose of the Study:
- To determine the clinical and histopathological characteristics of stasis ulcers in Behçet's syndrome patients.
- To evaluate treatment modalities and outcomes for these challenging leg ulcers.
Main Methods:
- A retrospective study of 63 Behçet's syndrome patients with stasis ulcers treated at a multidisciplinary center.
- Data collected included demographics, clinical features, histopathology, radiology, ulcer characteristics, and treatment regimens.
Main Results:
- Stasis ulcers appeared a median of 3 years after vascular involvement onset, with 56% presenting active ulcers at evaluation.
- The median ulcer size was 3 cm, predominantly in the gaiter region. Histopathology favored stasis dermatitis in most cases.
- Despite intensive treatment including immunosuppression, 17% of ulcers remained unhealed, and the recurrence rate was 73% over a median follow-up of 16.8 years.
Conclusions:
- Leg ulcers are challenging complications of DVT in Behçet's syndrome, highlighting an unmet medical need.
- Future research should focus on early immunosuppressive therapy and other interventions to prevent venous ulcers and improve outcomes.
Related Concept Videos
01:28Esophageal Varices-II: Clinical Features and Management
37
Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
In the initial assessment, a thorough review of the patient's medical history is vital to identify risk factors such as liver disease, alcohol...
37
01:24Esophageal Varices-I: Introduction
65
Esophageal varices are dilated, tortuous veins which are found mainly in the submucosa of the lower esophagus but which may also appear higher up or extend into the stomach. They develop due to increased pressure in the portal venous system, often as a result of liver cirrhosis. This condition scars and damages the liver, impeding normal blood flow through the portal vein. To compensate, blood seeks alternative pathways, forming fragile new vessels (varices) in the esophagus and stomach. These...
65
01:30Peptic Ulcer Disease I: Introduction
123
Peptic Ulcer Disease (PUD) is characterized by mucosal excavation in the esophagus, stomach, pylorus, or duodenum. It can manifest as acute or chronic based on the extent and duration of mucosal involvement.
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
123
01:27Assessment of the Cardiovascular System III: Palpation
176
Palpation involves feeling the body to evaluate texture, size, consistency, and tenderness for assessing cardiovascular health. The following steps are organized in a head-to-toe order:
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
Jugular Venous Pressure (JVP) Measurement
Position the patient at a thirty- to forty-five-degree angle or in a semi-fowler's position. Look for the highest point of pulsation in the internal jugular vein and measure the vertical distance to the angle of Loius or sternal angle. A normal JVP is 3-4 cm above...
176
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
126
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
126
01:17Chronic Bowel Disorders: Introduction
384
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
384