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Updated: May 28, 2025
Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
Published on: September 13, 2022
Differential Diagnosis of Early-Stage Atypical Primary Central Nervous System Lymphoma and Low-Grade Glioma Using
Kaiyang Zhao1, Yujiao Deng2, Xiaorui Su3
1Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu, China; Department of Radiology, West China Hospital of Sichuan University, Chengdu, China; Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu, China.
Background:
Different from typical primary central nervous system lymphoma (PCNSL), early-stage atypical PCNSL usually presents as patchy signal abnormalities without evident mass effect or significant contrast enhancement and is prone to confusion with low-grade glioma (LGG). This study aims to develop a magnetic resonance imaging (MRI)-based radiomics model to differentiate early-stage atypical PCNSL from LGG.
Methods:
Two cohorts consisting of early-stage atypical PCNSL patients, as well as LGG patients with similar radiological manifestations, were retrospectively recruited from West China Hospital of Sichuan University (PCNSL = 75; LGG = 138) and Chengdu Shangjin Nanfu Hospital (PCNSL = 35; LGG = 72) to serve as the training set and external validation set, respectively. Within the training set, there were additional early-stage atypical lesions from 19 typical or advanced-stage PCNSL patients included as a supplement. MRI-based radiomics models were developed and validated based on these 2 cohorts.
Results:
Nine radiomic features were selected as significant features, most of which are wavelet radiomic features. The best radiomics model achieved an area under the curve of 0.929 (0.901-0.957) and an accuracy of 91.6% on the independent external validation set. The inclusion of 19 additional PCNSL patients improved the model's performance.
Conclusions:
The MRI-based radiomics model can accurately differentiate early-stage atypical PCNSL from LGG with similar radiological manifestations, allowing early-stage atypical PCNSL patients to receive timely and appropriate radiotherapy or chemotherapy while avoiding unnecessary surgical resection.
