Related Experiment Video
Updated: May 28, 2025

Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
Progression in Parkinson's Disease
Krithi Irmady1, Serge Przedborski2
1Laboratory of Molecular Neuro-oncology, The Rockefeller University, New York, New York 10065, USA kirmady@rockefeller.edu sp30@cumc.columbia.edu.
Abstract:
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by relentlessly progressive motor and nonmotor clinical features. In this paper, we offer a comprehensive overview of progression in PD, covering the heterogeneous symptomatology crucial for monitoring progression from clinical, pathological, and biomarker perspectives. We also discuss prevailing theories concerning the underlying pathobiology driving progression in PD and summarize the literature on emerging biomarkers that are expected to facilitate early prognosis and effective monitoring of disease progression.
Related Concept Videos
Parkinson's Disease: Overview
Parkinson's Disease: Treatment
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Neural Regulation
Tumor Progression
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...

