Related Experiment Video
Updated: May 28, 2025
23:53
Ole Isacson: Development of New Therapies for Parkinson's Disease
Published on: April 29, 2007
7.9K
Progression in Parkinson's Disease.
Krithi Irmady1, Serge Przedborski2
1Laboratory of Molecular Neuro-oncology, The Rockefeller University, New York, New York 10065, USA kirmady@rockefeller.edu sp30@cumc.columbia.edu.
Cold Spring Harbor Perspectives in Medicine
|February 10, 2025
Summary
This paper reviews Parkinson's disease (PD) progression, detailing its varied symptoms and underlying biology. It highlights new biomarkers for earlier diagnosis and better monitoring of this neurodegenerative disorder.
Area of Science:
- Neuroscience
- Neurology
- Pathobiology
Background:
- Parkinson's disease (PD) is a common neurodegenerative disorder.
- Characterized by progressive motor and nonmotor symptoms.
Purpose of the Study:
- Provide a comprehensive overview of Parkinson's disease progression.
- Discuss the heterogeneous symptomatology, clinical, pathological, and biomarker perspectives.
- Summarize emerging biomarkers for early prognosis and monitoring.
Main Methods:
- Literature review of Parkinson's disease progression.
- Analysis of clinical, pathological, and biomarker data.
- Discussion of pathobiological theories.
Main Results:
- PD progression involves diverse motor and nonmotor features.
- Understanding progression requires integrating clinical, pathological, and biomarker insights.
- Emerging biomarkers show promise for early detection and monitoring.
Conclusions:
- Comprehensive understanding of PD progression is crucial.
- Biomarkers are key for future prognosis and monitoring strategies.
- Further research into pathobiology will refine treatment approaches.
Related Concept Videos
01:15Parkinson's Disease: Overview
436
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
436
01:24Parkinson's Disease: Treatment
189
Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of...
189
01:37Neural Regulation
39.1K
Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
39.1K
02:07Tumor Progression
6.2K
Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.2K
01:26Alzheimer's Disease: Overview
432
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
432