Predictive value and mediating effect analysis of the AHR-ARNT-CYP1A1 axis for missed abortion related to polycyclic aromatic hydrocarbons exposure
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View abstract on PubMed
Summary
This summary is machine-generated.Polycyclic aromatic hydrocarbons (PAHs) exposure is linked to missed abortion through aryl hydrocarbon receptor (AHR) signaling. The AHR-ARNT-CYP1A1 gene axis shows good predictive value for missed abortion risk.
Area Of Science
- Environmental Toxicology
- Reproductive Biology
- Molecular Genetics
Background
- Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants linked to adverse health outcomes.
- The aryl hydrocarbon receptor (AHR) signaling pathway plays a crucial role in mediating the toxic effects of PAHs.
- Missed abortion is a pregnancy complication with multifactorial causes, including environmental exposures.
Purpose Of The Study
- To evaluate the predictive value of AHR signaling pathway genes for missed abortion.
- To investigate the mediating role of AHR in the association between PAHs exposure and missed abortion.
Main Methods
- A 1:2 matched case-control study involving 94 women with missed abortion and 188 controls.
- Measurement of PAH-DNA adducts and gene expression levels (AHR, ARNT, AHRR, CYP1A1, GSTP1).
- Receiver Operating Characteristic (ROC) curve analysis and mediation analysis using R language.
Main Results
- PAH-DNA adduct levels were significantly higher in the missed abortion group.
- Significant differences in AHR, ARNT, AHRR, CYP1A1, and GSTP1 gene expression between groups.
- High PAH exposure increased AHR and CYP1A1 expression.
- The AHR-ARNT-CYP1A1 axis demonstrated good predictive performance (AUC=0.931) for missed abortion risk.
- AHR partially mediated the effect of PAHs on missed abortion (36.56% mediation).
Conclusions
- AHR signaling pathway genes, particularly the AHR-ARNT-CYP1A1 axis, are valuable predictors of missed abortion risk.
- AHR plays a significant mediating role in the pathway linking PAHs exposure to missed abortion.
- These findings highlight the impact of environmental pollutants on reproductive health and suggest potential therapeutic targets.
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