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Prominence of Microbiota to Predict Fibrous Stenosis in Crohn's Disease

  • 0Department of Gastroenterology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, People's Republic of China.
Journal of Inflammation Research +

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February 11, 2025

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February 11, 2025

View abstract on PubMed

Summary

This summary is machine-generated.

Fecal microbiota composition and function are altered in Crohn's disease (CD) patients with intestinal fibrous stenosis. Specific bacterial taxa and metabolic pathways show predictive potential for this common CD complication.

Area Of Science

  • Gastroenterology
  • Microbiome Research
  • Genomics

Background

  • Intestinal fibrous stenosis is a frequent complication of Crohn's disease (CD).
  • Predicting fibrous stenosis in CD remains challenging despite identified clinical risk factors.
  • The role of the intestinal microbiota in CD-associated fibrous stenosis is not well understood.

Purpose Of The Study

  • To investigate the role of fecal microbiota in the development of intestinal fibrous stenosis in Crohn's disease patients.
  • To identify specific microbial taxa and functional pathways associated with fibrous stenosis in CD.
  • To assess the predictive accuracy of fecal microbiota for CD-associated fibrous stenosis.

Main Methods

  • Metagenomic analysis of fecal samples from CD patients with and without intestinal fibrous stenosis.
  • Comparison of gut microbiota structure, composition, and function between the two groups.
  • Identification of differentially abundant taxa and enriched metabolic pathways using LEfSe and KEGG analysis.

Main Results

  • No significant differences in overall gut microbiota structure (alpha and beta diversity) were observed.
  • Seventy bacterial taxa showed significantly different abundance between groups.
  • Specific taxa, including *g_Bacteroides* and *g_Enterocloster*, predicted stenosis, while others predicted non-stenosis CD.
  • Differential enrichment in metabolic pathways like sphingolipid metabolism was noted in stenotic CD patients.

Conclusions

  • Fecal microbiota composition and function are significantly impacted in CD-associated intestinal fibrous stenosis.
  • Despite no overall structural differences, specific microbial changes and functional pathways hold potential for predicting fibrous stenosis in CD.
  • Further research into fecal microbiota may lead to novel diagnostic or therapeutic strategies for CD-related stenosis.

Keywords:

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