Polymeric nanocarriers for therapeutic gene delivery

Area of Science:

• Biomedical Engineering
• Nanotechnology
• Gene Therapy

Background:

• Gene therapy advancements are driving demand for effective gene delivery vectors.
• Viral and lipid-based nanocarriers are currently dominant but have limitations.
• Polymeric nanocarriers present versatile functionalities for improved nucleic acid drug delivery.

Purpose of the Study:

• To provide an overview of polymeric nanocarriers for therapeutic gene delivery.
• To highlight key cationic polymers, nanocarrier types, and preparation methods.
• To discuss targeted diseases, strategies for enhancing delivery efficiency, and future research directions.

Main Methods:

• Literature review focusing on polymeric nanocarriers in gene therapy.
• Analysis of existing research on cationic polymers and nanocarrier systems.
• Examination of strategies for improving stability, cellular uptake, and endosomal escape.

Main Results:

• Polymeric nanocarriers demonstrate potential for enhanced stability, cellular uptake, and endosomal escape.
• Versatile functionalities enable precise delivery to targeted tissues.
• Various preparation methods and cationic polymers are suitable for gene delivery applications.

Conclusions:

• Polymeric nanocarriers are emerging as a promising platform for therapeutic gene delivery.
• Further development and optimization are needed for clinical translation.
• This field holds significant potential for advancing gene therapy applications.