Photoredox-catalyzed deoxygenative radical transformation of alcohols to sulfinamides
Xinyu Zhu1, Junliang Wu1, Junliang Zhang2,3,4
1Henan Institute of Advanced Technology, Zhengzhou University Zhengzhou 450001 China wujl@zzu.edu.cn.
Abstract:
Sulfinamides play a crucial role in organic synthesis and pharmaceuticals. In this study, we introduce a highly effective method for the deoxygenative radical addition to N-tritylsulfinylamine, which produces sulfinamides via photoredox catalysis. This method is compatible with a diverse array of functional groups and the resulting sulfonamides were achieved in moderate to high yields. Furthermore, the synthetic applications to access various sulfur(vi)-centered functional groups highlight the practicality of this approach.
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