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Application of Nanomaterial-Mediated Ferroptosis Regulation in Kidney Disease
Jiamin Zhu1, Zhen Zhang1,2, Yanhui Chu1
1Heilongjiang Key Laboratory of Anti-Fibrosis Biotherapy, Mudanjiang Medical University, Mudanjiang, People's Republic of China.
Abstract:
Kidney diseases are a significant global cause of death and disability, resulting from the destruction of kidney structure and function due to an imbalance between the death of renal parenchymal cells and the proliferation or recruitment of maladaptive cells, caused by various pathogenic factors. Currently, therapies and their efficacy for kidney diseases are limited. Ferroptosis is a newly discovered iron-dependent regulated cell death. The imbalance of iron homeostasis and lipid metabolism affects the occurrence and progression of kidney diseases by triggering ferroptosis, which is considered an important target for the development of kidney disease drugs. However, in clinical practice, targeted ferroptosis therapy for kidney diseases faces obstacles such as poor drug solubility, low drug resistance, and imprecise targeting. With the rapid development of nanomaterials in the medical field, new opportunities have emerged for the precise regulation of ferroptosis in the treatment of kidney diseases. This article provides a detailed introduction to the regulatory mechanisms of ferroptosis, the properties of nanomaterials, and their application in the treatment of kidney diseases, with a focus on discussing the mechanisms of action and therapeutic potential of nanomaterials based on ferroptosis regulation in kidney diseases. The aim of this article is to provide new ideas and directions for future kidney disease treatments.
Insights
Ferroptosis, a cell death pathway, is implicated in kidney disease progression. Nanomaterials offer new strategies to precisely target ferroptosis for improved kidney disease treatments.
Area of Science:
- Biomedical Engineering
- Nephrology
- Cell Biology
Background:
- Kidney diseases cause significant global mortality and disability due to impaired kidney structure and function.
- Current therapies for kidney diseases are limited in efficacy.
- Ferroptosis, an iron-dependent regulated cell death, is increasingly recognized for its role in kidney disease pathogenesis.
Purpose of the Study:
- To explore the role of ferroptosis in kidney diseases.
- To investigate the potential of nanomaterials in regulating ferroptosis for kidney disease treatment.
- To provide insights into novel therapeutic strategies for kidney diseases.
Main Methods:
- Review of ferroptosis regulatory mechanisms.
- Analysis of nanomaterial properties relevant to drug delivery.
- Discussion of nanomaterial-based ferroptosis regulation in kidney disease models.
Main Results:
- Ferroptosis, driven by iron and lipid metabolism imbalance, contributes to kidney disease.
- Nanomaterials present opportunities to overcome challenges in targeted ferroptosis therapy, such as poor solubility and imprecise targeting.
- Nanomaterial-based strategies show therapeutic potential for kidney diseases by modulating ferroptosis.
Conclusions:
- Nanomaterials offer a promising avenue for precise ferroptosis regulation in treating kidney diseases.
- Targeted ferroptosis therapy using nanomaterials could overcome existing treatment limitations.
- This review provides a foundation for developing innovative nanomaterial-based treatments for kidney diseases.
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