Decompensated Liver Cirrhosis Research Network (UK-CLIF): Building consensus for hepatology trials in the UK

Area of Science:

• Hepatology and Gastroenterology
• Clinical Trial Management
• Health Services Research

Background:

• Liver disease, particularly cirrhosis, is a growing cause of mortality in the UK.
• The UK Chronic Liver Failure network (UK-CLIF) was initiated to address research gaps in high-prevalence or under-researched areas.
• A multi-stakeholder approach was adopted to foster collaboration in advancing cirrhosis research.

Purpose of the Study:

• To establish a network for advancing cirrhosis research in the UK.
• To identify key barriers and priorities for cirrhosis clinical trials through multi-stakeholder engagement.
• To develop consensus on critical areas for improving cirrhosis research infrastructure and delivery.

Main Methods:

• Network development via dissemination and snowball sampling, with online monitoring.
• Facilitated in-person workshops utilizing World Café methodology and dot voting.
• Thematic analysis of participant input to identify barriers and research priorities.

Main Results:

• Significant barriers to cirrhosis clinical trials include the need for patient-centric materials and insufficient clinician resources.
• Variability in the standard of inpatient care for cirrhosis was identified as a challenge.
• Consensus was reached on priority areas for research infrastructure, clinical factors, and future trial priorities.

Conclusions:

• The UK-CLIF network successfully engaged diverse stakeholders to identify critical issues in cirrhosis research.
• Addressing patient needs, enhancing clinician support, and standardizing inpatient care are crucial for improving clinical trial delivery.
• Future UK-CLIF activities will focus on quality improvement and coordinating a priority setting partnership for liver cirrhosis research.