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Recent Trends in Achievement Rates and Time Required for Left Ventricular Reverse Remodeling in Dilated

Masahiro Wanezaki1, Tetsu Watanabe1, Atsushi Iizuka1

  • 1Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine Yamagata Japan.

Circulation Reports
|February 11, 2025
PubMed

Insights

Left ventricular reverse remodeling (LVRR) rates in dilated cardiomyopathy (DCM) are increasing, with faster achievement times. Higher beta-blocker doses and lower B-type natriuretic peptide (BNP) levels at discharge are linked to LVRR success.

Area of Science:

  • Cardiology
  • Heart Failure Research

Background:

  • Dilated cardiomyopathy (DCM) is a significant cause of heart failure.
  • Left ventricular reverse remodeling (LVRR) is a positive prognostic indicator in DCM patients.

Purpose of the Study:

  • To investigate LVRR achievement rates, time to LVRR, and associated factors in recent DCM cases.
  • To analyze trends in LVRR over different time periods.

Main Methods:

  • Retrospective analysis of 121 DCM patients.
  • LVRR defined as left ventricular ejection fraction ≥40% with ≥10% improvement.
  • Multivariate analysis to identify factors associated with LVRR.

Main Results:

  • LVRR was achieved in 68% of patients (82/121) with a median time of 208 days.
  • Higher beta-blocker dose (OR 3.379) and lower discharge B-type natriuretic peptide (BNP) levels (OR 0.483) were independently associated with LVRR.
  • Recent period (2018-2022) showed significantly higher LVRR rates (89.5%) and shorter time to LVRR compared to the earlier period (2007-2017, 48.4%).

Conclusions:

  • LVRR achievement rates are increasing, and time to LVRR is decreasing in DCM.
  • Beta-blocker therapy and discharge BNP levels are key factors influencing LVRR in DCM.
Abstract

Keywords:
B-type natriuretic peptideBeta-blockersDilated cardiomyopathyLeft ventricular reverse remodeling

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