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Transcriptomic Signatures Predict Rubella Virus-Induced Cytokine and Chemokine Responses in Female MMR Recipients

Tamar Ratishvili1, Iana H Haralambieva1, Huy Q Quach1

  • 1Mayo Clinic Vaccine Research Group, Department of General Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA.

European Journal of Immunology
|February 11, 2025
PubMed

The study examined the relationship between rubella virus (RV)-induced gene expression and proinflammatory cytokine/chemokine secretion in females previously vaccinated with MMR. Gene clusters enriched for functional pathways of innate immune system activation and antiviral responses were found to predict RV-specific MCP-1, MCP-4, IP-10, and IL-2 secretion.

Keywords:
MMR vaccineWGCNAcytokine/chemokine responsesgene expressionpathway analysisrubella virustranscriptomic signatures

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