Related Experiment Video
Updated: May 28, 2025
Author Spotlight: Enhancing Rheumatoid Arthritis Research Through HR-pQCT Imaging Analysis
Published on: October 6, 2023
Fracture Risk Linked to Proton Pump Inhibitors Versus H2 Receptor Antagonists in Autoimmune Rheumatic and
Miaoyu Zeng1, Yung-Heng Lee2,3,4,5, Shiow-Ing Wang6,7
1Department of Radiology, Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, China.
Objective:
To understand if proton pump inhibitors (PPIs) usage associated with an increased risk of fractures among adult patients diagnosed with autoimmune rheumatic and gastrointestinal diseases, compared with H2 receptor antagonists (H2RAs) usage.
Methods:
We used the TriNetX US collaborative database for the study, which includes detailed demographic information, diagnostic and procedural data, medication details, laboratory results, genomic information, and healthcare utilization metrics. We analyzed 61 healthcare organizations to compare fracture risks associated with PPIs and H2RAs in adults, particularly those diagnosed with autoimmune rheumatic and gastrointestinal diseases. Propensity score matching acted as a control for demographic and clinical variables.
Results:
The study involved 1 717 598 patients, focusing on 16 299 who were new users of PPIs and 16 299 H2RAs users after propensity score matching. Over a 24-month follow-up period, no significant differences in fracture risks were observed between the PPI and H2RA groups in the overall cohort (hazard ratio, HR = 1.369, 95% confidence interval, CI = 0.933-2.009). However, subgroup analysis indicated that senior patients (≥ 65 years) who had been administered PPIs experienced a significantly higher risk of fractures (HR = 1.927 [1.153-3.221]), particularly non-vertebral fractures (HR = 2.379 [1.214-4.661]), when compared to their counterparts who had been prescribed H2RAs. Notably, the simultaneous use of PPIs and glucocorticoids further increased the fracture risk (HR = 4.273 [2.219-8.227]).
Conclusions:
The study demonstrates that patients diagnosed with autoimmune rheumatic and gastrointestinal diseases who were aged 65+ face increased fracture risks when using PPIs, particularly when there is a simultaneous intake of glucocorticoids.
More Related Videos
07:38Multimodal Quantitative Phase Imaging with Digital Holographic Microscopy Accurately Assesses Intestinal Inflammation and Epithelial Wound Healing
Published on: September 13, 2016
04:49Preliminary Study on Acupuncture Combined with Grain-sized Moxibustion for Treating Rheumatoid Arthritis with Finger Joint Pain
Published on: May 16, 2025
Related Concept Videos
01:26Peptic Ulcer Disease IV: Management
The therapeutic approach involves ensuring adequate rest, implementing drug therapy, promoting smoking cessation, making dietary modifications, and emphasizing long-term follow-up care.
Pharmacological management
The prevailing therapy for peptic ulcers involves a combination of managing the patient's current...
01:13Acid Suppressive Drugs for Peptic Ulcer Disease: Proton Pump Inhibitors
Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
01:30Peptic Ulcer Disease I: Introduction
An acute ulcer, marked by superficial erosion and minimal inflammation, swiftly resolves upon identifying and addressing the underlying cause. In contrast, a chronic ulcer persists, potentially eroding through the muscular wall and forming fibrous tissue.
Peptic ulcers can also be...
01:28Acid Suppressive Drugs for Peptic Ulcer Disease: Histamine H2-Receptor Antagonists
01:22Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds...
01:24Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors