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Published on: September 11, 2015
In vitro Bone Tissue Engineering Strategies: The Relevance of Cells and Culturing Methods in Bone Formation and
Ana Raquel Bastos1,2, Fátima Raquel Maia1,2, Joaquim Miguel Oliveira1,2
13B's Research Group, I3Bs - Research Institute on Biomaterials, Biodegradables and Biomimetics, University of Minho, Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine, Avepark - Parque de Ciência e Tecnologia Rua Ave 1, Edifício 1 (Sede), Barco, 4805-694, GMR - Portugal.
Bone tissue engineering (BTE) advances create realistic 3D models for studying bone diseases like osteoporosis. This review covers biomaterials, cells, and strategies for healthy bone formation and remodeling, including resorption.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Regenerative Medicine
Background:
- Bone tissue engineering (BTE) aims to replicate native bone using 3D scaffolds, growth factors, and cells.
- Current BTE research focuses on biomaterials and cell integration for bone formation.
- Existing studies often neglect the crucial bone resorption aspect of remodeling.
Purpose of the Study:
- To review current advancements in BTE for creating realistic bone tissue models.
- To explore strategies for achieving healthy bone formation and remodeling, including resorption.
- To discuss biomaterials, cell types, and drug delivery systems for bone disease treatment.
Main Methods:
- Review of current mono- and co-culturing methods in BTE.
- Analysis of various biomaterials used in combination with cells (osteoblasts, osteoclasts, osteocytes).
- Evaluation of drug delivery systems and bioengineered approaches for bone diseases.
Main Results:
- 3D tissue models offer more realistic tools for studying bone disorders like osteoporosis.
- Development of advanced biomaterials and cell combinations to mimic the bone microenvironment.
- Identification of gaps in research, particularly regarding the bone resorption process in BTE.
Conclusions:
- BTE holds significant promise for developing better models and treatments for bone diseases.
- A comprehensive approach including bone resorption is necessary for successful BTE.
- Further research into integrated biomaterial, cell, and drug delivery systems is crucial for effective bone regeneration and repair.
