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Thyroid disease as a comorbidity in inflammatory rheumatic diseases
Yuliya Fedorchenko1, Marlen Yessirkepov2, Bohdana Doskaliuk3
1Department of Pathophysiology, Ivano-Frankivsk National Medical University, Ivano-Frankivsk, Ukraine. juliakozubash@gmail.com.
Rheumatology International
|February 11, 2025
Summary
Thyroid disease frequently occurs with inflammatory rheumatic diseases (IRDs) due to shared autoimmune factors. Routine screening and targeted therapies are recommended for better management of these interconnected conditions.
Area of Science:
- Rheumatology
- Endocrinology
- Immunology
Background:
- Thyroid disease is a common comorbidity in patients with inflammatory rheumatic diseases (IRDs).
- The relationship is complex, influenced by shared autoimmune pathways and systemic inflammation.
- Conditions like rheumatoid arthritis, lupus, and scleroderma increase the risk of thyroid dysfunction.
Purpose of the Study:
- To explore the mechanisms linking thyroid disease and IRDs.
- To review the implications for managing IRDs and thyroid conditions.
- To highlight strategies for optimizing patient outcomes in these overlapping conditions.
Main Methods:
- Review of existing literature on thyroid disease in IRDs.
- Analysis of shared autoimmune mechanisms and inflammatory pathways.
- Evaluation of current and emerging therapeutic strategies.
Main Results:
- Rheumatoid arthritis, SLE, and SSc are associated with higher risks of hypothyroidism, hyperthyroidism, and AITD.
- Routine thyroid screening is advised for high-risk IRD populations.
- Targeted therapies, including anti-TNF-α and anti-IL-17 agents, show promise.
Conclusions:
- An integrated management approach is essential for patients with co-existing thyroid disease and IRDs.
- Early detection and tailored treatments can significantly improve patient outcomes.
- Further research into the interplay between these conditions is warranted.
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