Real-World Osteoporosis Treatment Gap and Costs in Spain: Data from Women with a First Fragility Fracture or Diagnosis of Postmenopausal Osteoporosis
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View abstract on PubMed
Summary
This summary is machine-generated.A significant treatment gap exists for postmenopausal osteoporosis (PMO) in Spanish women over 50. Addressing this gap and improving treatment adherence can reduce fracture risk and healthcare costs.
Area Of Science
- Bone Health and Osteoporosis Research
- Real-World Evidence in Healthcare
- Pharmacoeconomics and Healthcare Management
Background
- Postmenopausal osteoporosis (PMO) significantly elevates fragility fracture (FF) risk, leading to disability and increased mortality.
- Despite available treatments, osteoporosis (OP) remains undertreated in high-risk postmenopausal women.
- Limited real-world data exists on OP care patterns and outcomes in Spain.
Purpose Of The Study
- To assess the OP treatment gap in Spanish women aged ≥50 years following a first FF or PMO diagnosis.
- To evaluate healthcare resource utilization (HCRU) and associated costs in these patient cohorts.
- To identify factors influencing treatment persistence and fracture incidence.
Main Methods
- Retrospective analysis of the BIG-PAC® administrative database (2014-2018).
- Inclusion of women ≥50 years with a first FF (cohort 1) or new PMO diagnosis (cohort 2).
- Two-year follow-up to determine treatment gap, fracture rates, mortality, HCRU, and costs.
Main Results
- A substantial OP treatment gap was observed: 41.5% in the FF cohort vs. 23.6% in the PMO cohort.
- Women in the FF cohort experienced higher rates of subsequent fractures (88%) and incurred significantly higher 2-year costs (€10,601 vs. €1659).
- Prescribed OP treatment and treatment persistence were associated with lower fracture rates and costs.
Conclusions
- A significant treatment gap in OP management exists for Spanish women aged ≥50, particularly those with a first FF.
- High healthcare costs are associated with FF, especially hip and vertebral fractures.
- Improving OP treatment adherence is crucial for reducing fracture risk, healthcare expenditure, and resource utilization.
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