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Accelerated Intermittent Theta-Burst Stimulation for Treatment-Resistant Bipolar Depression: A Randomized Clinical

Lawrence G Appelbaum1, Hadley Daniels1, Liam Lochhead1

  • 1Department of Psychiatry, Interventional Psychiatry Program, University of California San Diego, La Jolla.

JAMA Network Open
|February 11, 2025
PubMed
Abstract

No abstract available in PubMed .

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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early...
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