Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Insomnia01:27

Insomnia

75
Insomnia is a prevalent sleep disorder characterized by difficulty falling asleep, frequent awakenings during the night, and waking up too early without being able to return to sleep. People with insomnia often experience these disruptions at least three nights a week for at least one month. Chronic insomnia, which lasts for at least three months, can lead to increased anxiety, which in turn can worsen sleep difficulties, creating a cycle of sleeplessness and stress.
Multiple factors contribute...
75
Management of Insomnia01:19

Management of Insomnia

182
The sleep cycle, an integral part of human health, consists of several stages with distinct characteristics and functions. It begins with a transition from wakefulness to sleep, known as the light sleep phase, followed by the restorative deep sleep phase, essential for physical recovery and growth. The cycle concludes with the Rapid Eye Movement (REM) phase, characterized by high brain activity and vivid dreaming. Insomnia, a prevalent sleep disorder, involves difficulty falling asleep, staying...
182
Sleep-Wake Cycles01:24

Sleep-Wake Cycles

1.1K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and  rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.1K
Insufficient Sleep and Sleep Deprivation01:13

Insufficient Sleep and Sleep Deprivation

118
Insufficient sleep refers to not getting the recommended amount of sleep for optimal functioning, even if it's just slightly less than needed. Sleep insufficiency may occur due to lifestyle choices, such as staying up late for social events or work, resulting in routinely getting less sleep than required. For example, consistently sleeping 6 hours when the body needs 7-9 hours can lead to cumulative effects on health and well-being.
Sleep deprivation is a more severe form of sleep loss...
118
Narcolepsy01:07

Narcolepsy

82
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
82
REM Sleep Behavior Disorder01:15

REM Sleep Behavior Disorder

108
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
108

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Protocol for the DREAMER study: Design and methodological framework of a multicenter trial-ready cohort of individuals with isolated REM sleep without atonia.

PloS one·2026
Same author

Clinical markers of disease progression in the prodromal to overt alpha-synucleinopathy continuum.

Brain : a journal of neurology·2026
Same author

Genetic associations between post-traumatic stress disorder and REM-sleep behavior disorder.

NPJ Parkinson's disease·2026
Same author

Spatio-temporal gait signatures across prodromal and early Parkinson's disease in two independent cohorts.

Scientific reports·2026
Same author

Daridorexant Treatment for Chronic Insomnia in Restless Legs Syndrome.

Movement disorders clinical practice·2026
Same author

Impact of Chronotype-Based scheduling on sleep EEG in first seizure Patients: A pilot study.

Epilepsy & behavior : E&B·2026
Same journal

How to become a centenarian in four weeks?. Myths and limits of longevity recipes: a critical review.

Minerva medica·2026
Same journal

Comparative efficacy and safety between intravenous recombinant human prourokinase and alteplase in acute ischemic stroke treatment: a meta-analysis of randomized controlled trials.

Minerva medica·2026
Same journal

Efficacy and safety of oral tapentadol for cancer-related pain: an updated systematic review and meta-analysis.

Minerva medica·2026
Same journal

Use of the neurostimulator in thyroidectomy procedures: comparison between vagal and recurrent laryngeal nerve stimulation.

Minerva medica·2026
Same journal

Iron deficiency and risk of acute kidney injury after TAVI: a machine learning analysis.

Minerva medica·2026
Same journal

Therapeutic adherence and health literacy: a perfect match in dyslipidemic patients.

Minerva medica·2026
See all related articles

Related Experiment Video

Updated: May 8, 2025

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.2K

Insomnia disorder.

Luigi Ferini-Strambi1

  • 1Sleep Disorders Center, Vita-Salute San Raffaele University, Milan, Italy - ferinistrambi.luigi@hsr.it.

Minerva Medica
|February 11, 2025
PubMed
Summary
This summary is machine-generated.

Insomnia significantly impacts public health, affecting quality of life and increasing health risks. Cognitive Behavioral Therapy for Insomnia (CBT-I) is the primary treatment, with medications like triazolam considered when CBT-I is insufficient.

More Related Videos

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.2K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

547

Related Experiment Videos

Last Updated: May 8, 2025

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System
05:59

Author Spotlight: Overcoming Challenges in Drosophila Sleep Measurement Using DAM System

Published on: October 20, 2023

2.2K
A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice
06:23

A Chronic Sleep Fragmentation Model using Vibrating Orbital Rotor to Induce Cognitive Deficit and Anxiety-Like Behavior in Young Wild-Type Mice

Published on: September 22, 2020

5.2K
Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression
04:33

Author Spotlight: Unveiling the Connection Between Sleep Disorders and Cognitive Symptoms in Depression

Published on: April 26, 2024

547

Area of Science:

  • Sleep Medicine
  • Public Health
  • Pharmacology

Background:

  • Insomnia is a widespread sleep disorder with significant daytime consequences.
  • It disproportionately affects women, older adults, and those with comorbid conditions.
  • Insomnia is linked to increased risks of various health problems, underscoring the need for effective management.

Purpose of the Study:

  • To review current treatment guidelines and pharmacological options for chronic insomnia.
  • To highlight the role of Cognitive Behavioral Therapy for Insomnia (CBT-I) as a first-line therapy.
  • To discuss the efficacy and safety of various pharmacologic agents, including benzodiazepines and orexin receptor antagonists.

Main Methods:

  • Review of existing literature and clinical guidelines on insomnia treatment.
  • Analysis of evidence supporting Cognitive Behavioral Therapy for Insomnia (CBT-I).
  • Evaluation of pharmacological interventions, including benzodiazepines, benzodiazepine receptor agonists, sedating antidepressants, and orexin receptor antagonists.

Main Results:

  • Cognitive Behavioral Therapy for Insomnia (CBT-I) is the recommended first-line treatment for chronic insomnia.
  • Pharmacological options, such as benzodiazepines (e.g., triazolam) and orexin receptor antagonists, are effective for short-term management.
  • Careful consideration of benefits and risks is necessary for longer-term medication use, and non-nightly hypnotic use may be appropriate.

Conclusions:

  • Effective management of insomnia is crucial for improving patient quality of life and reducing health burdens.
  • CBT-I is the preferred initial treatment, with pharmacotherapy reserved for specific cases or when CBT-I is ineffective.
  • Further research is needed to determine the cost-effectiveness of various insomnia treatments.