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Single-Molecule-Sensitive Three-Dimensional Atomic Heterostructures with Extreme Light-Matter Coupling
Yi-Jui Yeh1,2, Shao-Yu Chen2, Wesley Wei-Wen Hsiao1
1Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.
Journal of the American Chemical Society
|February 11, 2025
Summary
Plasma-assisted epitaxy enables novel three-dimensional heterostructures (3DHS) for ultrasensitive single-molecule detection. This scalable nanofabrication method offers a new platform for advanced biosensing and nanoelectronic applications.
Area of Science:
- Materials Science
- Nanotechnology
- Biomedical Engineering
Background:
- Three-dimensional heterostructures (3DHS) are crucial for various applications but face fabrication challenges.
- Conventional methods suffer from poor control, high cost, and hazardous chemical use.
Purpose of the Study:
- To engineer a metal-organic 3DHS with enhanced light-matter interaction for rapid single-molecule sensing.
- To develop a scalable and cost-effective nanofabrication method for advanced materials.
Main Methods:
- Utilized plasma-assisted epitaxy (PAE) for microplasma-enabled nanofabrication of gold-silver core-shell nanoparticles (AuAgCSNPs).
- Engineered plasmonic-active 3DHS under ambient conditions on flexible substrates.
Main Results:
- Achieved precise engineering of AuAgCSNP-based 3DHS with exceptional Raman enhancement.
- Demonstrated single-molecule detection of SARS-CoV-2 spike proteins using surface-enhanced Raman scattering (SERS).
Conclusions:
- Developed a scalable, ambient-condition plasma fabrication method for centimeter-scale SERS-active 3DHS.
- This technology opens new avenues for next-generation biosensing, nanoelectronics, and nanocatalysis.
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