Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Super-resolution Fluorescence Microscopy

Super-resolution Fluorescence Microscopy

Super-resolution fluorescence microscopy (SRFM) provides a better resolution than conventional fluorescence microscopy by reducing the point spread function (PSF). PSF is the light intensity distribution from a point that causes it to appear blurred. Due to PSF, each fluorescing point appears bigger than its actual size, and it is the PSF interference of nearby fluorophores that causes the blurred image. Various approaches to achieving higher resolution through SRFM have recently been...

¹H NMR: Long-Range Coupling

¹H NMR: Long-Range Coupling

The coupling interactions of nuclei across four or more bonds are usually weak, with J values less than 1 Hz. While these are usually not observed in spectra, the presence of multiple bonds along the coupling pathway can result in observable long-range coupling.
In alkenes, spin information is communicated via σ–π overlap, as seen in allylic (four-bond) and homoallylic (five-bond) couplings. These coupling interactions are stronger when the σ bond is parallel to the alkene...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

A proteomic atlas of organelle remodeling identifies lysosomal SNX3 as a regulator of Notch signaling in epidermal differentiation.

bioRxiv : the preprint server for biology·2026

Same author

Molecular Networks of Redox Dysregulation in Fetal Alcohol Spectrum Disorders: Mechanisms and Therapeutic Prospects.

Antioxidants (Basel, Switzerland)·2026

Same author

Quantum Dots as Emerging Nanomaterials for Sensitive and Selective Environmental Contaminant Sensing.

Chemistry, an Asian journal·2026

Same author

Racemic van der Waals Assembly of Planar-Chiral 2D Materials for Intrinsic One-Dimensional Moiré Superlattices.

ACS nano·2026

Same author

Application of the patient-reported and nurse-rated Richards-Campbell Sleep Questionnaire in neurorehabilitation inpatients.

Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine·2026

Same author

Nanobubbles, not microbubbles, enable ultrasound visualization of the perivascular space: A validation and focused ultrasound modulation study.

Ultrasonics·2026

Search research articles

Related Experiment Video

Updated: May 28, 2025

Hand Controlled Manipulation of Single Molecules via a Scanning Probe Microscope with a 3D Virtual Reality Interface

Hand Controlled Manipulation of Single Molecules via a Scanning Probe Microscope with a 3D Virtual Reality Interface

Published on: October 2, 2016

Single-Molecule-Sensitive Three-Dimensional Atomic Heterostructures with Extreme Light-Matter Coupling.

Yi-Jui Yeh^1,2, Shao-Yu Chen², Wesley Wei-Wen Hsiao¹

¹Department of Chemical Engineering, National Taiwan University of Science and Technology, Taipei 10607, Taiwan.

Journal of the American Chemical Society

|February 11, 2025

Summary

Plasma-assisted epitaxy enables novel three-dimensional heterostructures (3DHS) for ultrasensitive single-molecule detection. This scalable nanofabrication method offers a new platform for advanced biosensing and nanoelectronic applications.

More Related Videos

A Guide to Build a Highly Inclined Swept Tile Microscope for Extended Field-of-view Single-molecule Imaging

A Guide to Build a Highly Inclined Swept Tile Microscope for Extended Field-of-view Single-molecule Imaging

Published on: April 8, 2019

Atomically Traceable Nanostructure Fabrication

Atomically Traceable Nanostructure Fabrication

Published on: July 17, 2015

Related Experiment Videos

Last Updated: May 28, 2025

Hand Controlled Manipulation of Single Molecules via a Scanning Probe Microscope with a 3D Virtual Reality Interface

Hand Controlled Manipulation of Single Molecules via a Scanning Probe Microscope with a 3D Virtual Reality Interface

Published on: October 2, 2016

A Guide to Build a Highly Inclined Swept Tile Microscope for Extended Field-of-view Single-molecule Imaging

A Guide to Build a Highly Inclined Swept Tile Microscope for Extended Field-of-view Single-molecule Imaging

Published on: April 8, 2019

Atomically Traceable Nanostructure Fabrication

Atomically Traceable Nanostructure Fabrication

Published on: July 17, 2015

Area of Science:

Materials Science
Nanotechnology
Biomedical Engineering

Background:

Three-dimensional heterostructures (3DHS) are crucial for various applications but face fabrication challenges.
Conventional methods suffer from poor control, high cost, and hazardous chemical use.

Purpose of the Study:

To engineer a metal-organic 3DHS with enhanced light-matter interaction for rapid single-molecule sensing.
To develop a scalable and cost-effective nanofabrication method for advanced materials.

Main Methods:

Utilized plasma-assisted epitaxy (PAE) for microplasma-enabled nanofabrication of gold-silver core-shell nanoparticles (AuAgCSNPs).
Engineered plasmonic-active 3DHS under ambient conditions on flexible substrates.

Main Results:

Achieved precise engineering of AuAgCSNP-based 3DHS with exceptional Raman enhancement.
Demonstrated single-molecule detection of SARS-CoV-2 spike proteins using surface-enhanced Raman scattering (SERS).

Conclusions:

Developed a scalable, ambient-condition plasma fabrication method for centimeter-scale SERS-active 3DHS.
This technology opens new avenues for next-generation biosensing, nanoelectronics, and nanocatalysis.