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New software program to improve biometry measurements obtained by an optical low-coherence reflectometry biometer.
David L Cooke1, Tim L Cooke, Raj Patel
1From the Great Lakes Eye Care, St. Joseph, Michigan (D.L. Cooke, T.L. Cooke); Department of Neurology and Ophthalmology, Michigan State University, College of Osteopathic Medicine, East Lansing, Michigan (D.L. Cooke); Department of Ophthalmology, University of Missouri-Kansas City, Kansas City, Missouri (Patel); College of Medicine, University of Oklahoma, Oklahoma City, Oklahoma (Heath); College of Medicine, Wayne State University, Detroit, Michigan (Gardiner); Dean McGee Eye Institute, University of Oklahoma, Oklahoma City, Oklahoma (Murphy, Riaz).
SpikeFinder software significantly improves anterior chamber depth and lens thickness measurements from optical low-coherence reflectometry biometry. This enhancement aids in more accurate ophthalmic calculations.
Area of Science:
- Ophthalmology
- Biomedical Engineering
- Optical Metrology
Background:
- Optical low-coherence reflectometry (OLCR) biometry is crucial for intraocular lens calculations.
- Existing OLCR biometry systems may have measurement discrepancies, particularly in anterior chamber depth (ACD) and lens thickness (LT).
- Swept-source optical coherence tomography (SS-OCT) biometry serves as a comparative standard for these measurements.
Purpose of the Study:
- To evaluate the efficacy of a new software, SpikeFinder, in enhancing the accuracy of OLCR biometry measurements.
- To compare measurements obtained from OLCR biometry before and after SpikeFinder application against SS-OCT biometry.
- To assess the potential impact of improved measurements on ophthalmic formula performance.
Main Methods:
- A retrospective analysis of 12,988 eyes comparing OLCR biometry (LENSTAR) and SS-OCT biometry (IOLMaster700) measurements.
- Statistical comparison of axial length (AL), ACD, and LT between the two biometry methods.
- Application of SpikeFinder software to a subset of eyes with significant ACD and LT measurement differences.
- Heteroscedastic testing to evaluate measurement improvements post-SpikeFinder application.
Main Results:
- Axial length measurements showed high agreement (99.1% within 0.01 mm) between biometers.
- Significant differences were observed in LT (33% ≥0.50 mm longer in SS-OCT) and ACD (14% ≥0.50 mm shorter in SS-OCT) before software application (P < .001).
- After applying SpikeFinder to 337 eyes, ACD and LT differences were minimized to -0.02 ± 0.03 mm and 0.01 ± 0.11 mm, respectively, showing close agreement with SS-OCT values (P = .872 for ACD, P = .987 for LT).
Conclusions:
- The SpikeFinder software effectively improves the accuracy of ACD and LT measurements obtained via OLCR biometry.
- These improved measurements are comparable to those obtained with SS-OCT biometry.
- Enhanced accuracy in ACD and LT measurements has the potential to improve the performance of intraocular lens calculation formulas.
