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Halothane-relaxant anaesthesia in elderly patients.

L Tokics, B Brismar, G Hedenstierna

Acta Anaesthesiologica Scandinavica

|April 1, 1985

Summary

Elderly patients undergoing surgery showed reduced cardiac function and oxygen uptake with halothane anesthesia. This response, differing from younger individuals, suggests age impacts reactions to this anesthetic agent.

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Area of Science:

Anesthesiology
Geriatric Medicine
Cardiovascular Physiology

Background:

Halothane anesthesia is commonly used in surgical procedures.
The physiological effects of halothane can vary based on patient demographics.
Limited data exists on the specific cardiovascular responses of elderly patients to halothane.

Purpose of the Study:

To investigate the central hemodynamic effects of halothane anesthesia in elderly patients undergoing elective cholecystectomy.
To compare the cardiovascular response in elderly patients to known responses in younger populations.
To assess the influence of premedication and thiopentone induction on halothane anesthesia outcomes in this age group.

Main Methods:

Studied 23 elderly patients undergoing elective cholecystectomy.
Measured central hemodynamics awake and during halothane anesthesia at varying concentrations (0.5% and 1.0%).
Evaluated the impact of nitrous oxide addition and compared groups with and without thiopentone induction and premedication.

Main Results:

Halothane anesthesia led to decreased cardiac index, mean arterial blood pressure, and oxygen uptake in elderly patients.
No significant increase in right atrial or pulmonary capillary venous pressure was observed.
The arterio-venous oxygen content difference decreased, suggesting reduced systemic vascular resistance, differing from findings in younger subjects.

Conclusions:

Age significantly influences the cardiovascular response to halothane anesthesia.
The observed reductions in cardiac function and oxygen uptake are likely due to a dose-dependent decrease in systemic vascular resistance in the elderly.
Nitrous oxide had minimal impact on the central circulation in this patient cohort.

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