Related Experiment Video
Updated: Aug 18, 2026
Sex Stratified Neuronal Cultures to Study Ischemic Cell Death Pathways
Published on: December 9, 2013
Sex-Specific Cardiovascular Risks and Mortality in Patients with Panhypopituitarism: A Nationwide Cohort Study
Seung Shin Park1,2,3, Hyunmook Jeong4, Chang Ho Ahn5
1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
Insights
Patients with panhypopituitarism face significantly higher risks of cardiovascular and cerebrovascular diseases and increased mortality. These risks, especially for all-cause mortality, are notably higher in women, necessitating proactive monitoring.
Area of Science:
- Endocrinology
- Cardiovascular Medicine
- Neurology
Background:
- Panhypopituitarism involves multiple pituitary hormone deficiencies requiring lifelong hormone replacement.
- Inadequate hormone management or deficiency may increase cardiovascular disease risk.
Purpose of the Study:
- To investigate the burden of cardiovascular, cerebrovascular diseases, and mortality in panhypopituitarism patients.
- To compare disease risks and mortality rates between panhypopituitarism patients and matched controls.
Main Methods:
- Utilized Korean National Health Insurance Service database (2003-2020) with 5,714 panhypopituitarism patients.
- Defined panhypopituitarism using ICD-10 codes and continuous hormone prescription.
- Compared risks of mortality, coronary artery disease, heart failure, ischemic stroke, and intracranial hemorrhage with matched controls.
Main Results:
- Panhypopituitarism patients exhibited significantly higher all-cause mortality (HR 2.18 in men, 3.09 in women).
- Elevated risks of heart failure, ischemic stroke, and intracranial hemorrhage were observed in both sexes.
- Coronary artery disease risk was higher in women but not significantly in men.
Conclusions:
- Panhypopituitarism is associated with increased risks of cardiovascular and cerebrovascular diseases and mortality.
- Women with panhypopituitarism show particularly high all-cause mortality.
- Proactive monitoring for cardiovascular and cerebrovascular complications is crucial for these patients.
Backgruound:
Panhypopituitarism is a condition of combined deficiency of multiple pituitary hormones, which requires lifelong hormone replacement therapy. Hormone deficiency or inadequate hormone replacement may contribute to cardiovascular disease. Here, we aimed to investigate the burden of cardiovascular, cerebrovascular diseases and mortality in patients with panhypopituitarism.
Methods:
A total of 5,714 patients with panhypopituitarism were enrolled in the Korean National Health Insurance Service database from 2003 to 2020. Panhypopituitarism was defined according to the International Classification of Diseases, 10th Revision (ICD- 10) codes for hypopituitarism, pituitary adenoma, or craniopharyngioma and the continuous prescription of thyroid hormone and glucocorticoids. The risks of all-cause mortality, coronary artery disease (CAD), heart failure (HF), ischemic stroke, and intracranial hemorrhage were compared between patients with panhypopituitarism and age-, sex-, and index year-matched controls.
Results:
The mean age of patients with panhypopituitarism and matched controls was 55.1 years, and men accounted for 51.5%. Patients with panhypopituitarism showed significantly higher all-cause mortality compared to matched controls after adjustment for covariates (hazard ratio [HR], 2.18; 95% confidence interval [CI], 1.95 to 2.43 in men and HR, 3.09; 95% CI, 2.78 to 3.44 in women). Additionally, there were higher risks of CAD, HF, ischemic stroke, and intracranial hemorrhage in both sexes, except for CAD in men.
Conclusion:
Patients with panhypopituitarism have elevated risks of cardiovascular and cerebrovascular diseases as well as increased mortality. These risks are particularly prominent for all-cause mortality in women. Therefore, proactive monitoring for cardiovascular and cerebrovascular complications is required in patients with panhypopituitarism.
More Related Videos
07:51Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis
Published on: September 26, 2018
14:35Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Published on: April 17, 2021
