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A Research Method For Detecting Transient Myocardial Ischemia In Patients With Suspected Acute Coronary Syndrome Using Continuous ST-segment Analysis

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Hypothyroidism is a risk factor for transient ischemic attack: A meta-analysis.

Jian Li¹, Hui Liu¹, Yan Li¹

¹From the Department of Neurology, Huantai County People's Hospital, Shandong, China.

Saudi Medical Journal

|February 11, 2025

Summary

Hypothyroidism, especially clinical hypothyroidism, is a significant risk factor for transient ischemic attack (TIA). This meta-analysis confirms the association, highlighting the importance of managing thyroid health to prevent stroke events.

Keywords:

hypothyroidism meta analysis thyroid-stimulating hormone thyroxine transient ischemic attack

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Area of Science:

Endocrinology
Neurology
Public Health

Background:

Hypothyroidism is a common endocrine disorder.
Transient ischemic attack (TIA) is a critical warning sign for stroke.
The relationship between hypothyroidism and TIA risk requires further clarification.

Purpose of the Study:

To systematically evaluate the association between hypothyroidism and the risk of transient ischemic attack (TIA).
To differentiate the risk associated with clinical versus subclinical hypothyroidism.

Main Methods:

A comprehensive literature search was conducted across multiple databases including Embase, PubMed, and Cochrane.
Data extraction and analysis were performed by two independent researchers.
Meta-analysis was conducted using Review Manager 5.3 software to synthesize findings from 7 studies.

Main Results:

Seven studies comprising 190,248 participants were included in the meta-analysis.
Hypothyroidism was significantly associated with an increased risk of TIA (RR=1.43, 95% CI: [1.29-1.57]).
The association was significant for clinical hypothyroidism (RR=1.45, 95% CI: [1.31-1.62]) but not for subclinical hypothyroidism (RR=1.20, 95% CI: [0.90-1.61]).

Conclusions:

Hypothyroidism, particularly clinical hypothyroidism, emerges as a potential independent risk factor for TIA.
These findings underscore the importance of considering thyroid status in TIA risk assessment and prevention strategies.