Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drug Accumulation During Multiple Dosing: Repetitive IV Injections01:21

Drug Accumulation During Multiple Dosing: Repetitive IV Injections

526
Calculating drug dosage and accumulation in multiple-dose regimens is crucial for achieving therapeutic efficacy while avoiding toxicity. This involves determining the plasma drug concentrations over time to optimize dosing schedules. The principle of superposition is fundamental in this process, allowing for the prediction of drug concentration in plasma following multiple doses based on single-dose data.The principle of superposition asserts that the plasma concentration-time curves from...
526

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Menopause and musculoskeletal health in English primary care: study protocol.

BJGP open·2026
Same author

Monitoring of the Cascade of Care in Patients With Chronic HBV in Primary Care Clinics in Australia.

Journal of viral hepatitis·2026
Same author

APASL clinical practice guidelines on the management of chronic hepatitis B infection: a 2026 update.

Hepatology international·2026
Same author

Impact of Antiviral Therapy Scale-Up Among People Who Inject Drugs in Scotland: Regional Evidence of Hepatitis C Virus Elimination.

Liver international : official journal of the International Association for the Study of the Liver·2026
Same author

Trajectories of brain structure and function in young adult carriers of genetic frontotemporal dementia variants.

medRxiv : the preprint server for health sciences·2026
Same author

Health, Social and Recidivism Outcomes Among People Who Have Been Incarcerated in New South Wales, Australia: Study Protocol and Cohort Profile for the Prison Outcomes STudy (POST).

Drug and alcohol review·2026

Related Experiment Video

Updated: Apr 28, 2026

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior
10:05

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

Published on: September 16, 2015

14.3K

Supervised Injecting Room Cohort Study (SIRX): study protocol.

Ashleigh C Stewart1,2, Matthew Hickman3,4,5, Paul A Agius3,6

  • 1Disease Elimination, Burnet Institute, Melburne, Victoria, Australia ashleigh.stewart@burnet.edu.au.

BMJ Open
|February 11, 2025
PubMed
Summary
This summary is machine-generated.

The Supervised Injecting Room Cohort Study (SIRX) evaluates the impact of supervised injecting facilities (SIFs) on drug-related harms and health service use. Findings will inform harm reduction strategies and SIF effectiveness.

Keywords:
Drug UtilizationHealth ServicesSubstance misuse

More Related Videos

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

10.5K
A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
08:05

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

2.5K

Related Experiment Videos

Last Updated: Apr 28, 2026

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior
10:05

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior

Published on: September 16, 2015

14.3K
A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

10.5K
A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence
08:05

A Procedure to Study Stress-Induced Relapse of Heroin Seeking after Punishment-Imposed Abstinence

Published on: March 23, 2022

2.5K

Area of Science:

  • Public Health
  • Epidemiology
  • Health Services Research

Background:

  • Supervised injecting facilities (SIFs) aim to mitigate harms from injecting drug use and improve service access.
  • The Melbourne Medically Supervised Injecting Room (MSIR) offers integrated harm reduction, health, and social support services.
  • The Supervised Injecting Room Cohort Study (SIRX) investigates the effects and cost-effectiveness of the MSIR.

Purpose of the Study:

  • To provide evidence on the effects of a SIF (MSIR) on health and social outcomes.
  • To assess the cost-effectiveness of the MSIR.
  • To evaluate the impact of MSIR exposure on health service utilization.

Main Methods:

  • Two prospective cohort studies: SuperMIX (ongoing since 2008) and SIRX-Registration Cohort (SIRX-R, established 2024).
  • Collection of behavioral data and linkage to administrative data (health services, criminal justice, mortality).
  • Causal inference methods to estimate the effect of MSIR exposure on primary outcomes like overdoses and mortality.

Main Results:

  • Primary outcomes include ambulance-attended non-fatal overdoses, all-cause mortality, and drug-related mortality.
  • Secondary outcomes focus on health service use and related impacts.
  • Analyses will compare outcomes based on frequency of MSIR use (frequent, infrequent, none).

Conclusions:

  • The SIRX study will generate crucial evidence on the effectiveness and cost-effectiveness of integrated SIFs.
  • Findings will inform public health policy and harm reduction strategies for people who inject drugs.
  • Dissemination includes scientific publications, conference presentations, and accessible summaries for stakeholders and participants.