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Updated: May 28, 2025

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging
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The emerging regulatory interface between DNA repair and steroid hormone receptors in cancer

Bim de Klein1, Nils Eickhoff1, Wilbert Zwart2

  • 1Division of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, The Netherlands.

Trends in Molecular Medicine
|February 11, 2025
PubMed

Insights

The DNA damage response (DDR) and steroid hormone receptors (SHRs) interact in cancer. This interplay influences gene expression and signaling, offering new therapeutic targets for breast and prostate cancers.

Area of Science:

  • Molecular Biology
  • Cancer Biology
  • Genetics

Background:

  • Human cells rely on transcriptional regulation and genome integrity for function.
  • The DNA damage response (DDR) maintains genome stability.
  • Steroid hormone receptors (SHRs) are key transcription factors regulating diverse cellular processes.

Purpose of the Study:

  • To review the interplay between DDR factors and SHR signaling in cancer.
  • To highlight recent developments and insights into this complex relationship.
  • To identify potential therapeutic interventions targeting this interplay.

Main Methods:

  • Literature review focusing on the intersection of DDR and SHR pathways.
  • Analysis of studies investigating SHR-DDR interactions in cancer models.
  • Synthesis of findings related to gene expression and signaling modulation.

Main Results:

  • SHRs can directly influence the expression of DDR genes.
  • DDR factors act as transcriptional coregulators for SHR signaling.
  • This interplay is implicated in oncogenic SHR-mediated signaling, particularly in breast and prostate cancers.

Conclusions:

  • The interaction between DDR and SHRs presents a significant axis in cancer development.
  • Targeting this crosstalk offers promising avenues for novel cancer therapies.
  • Further research into this complex interplay is warranted for clinical applications.
Keywords:
DNA damage repairsteroid hormone receptorstranscriptional regulation

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