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Analysis of Termination of Transcription Using BrUTP-strand-specific Transcription Run-on TRO Approach
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Promoter-proximal RNA polymerase II termination regulates transcription during human cell type transition

Kseniia Lysakovskaia1, Arjun Devadas1, Björn Schwalb1

  • 1Department of Molecular Biology, Max Planck Institute for Multidisciplinary Sciences, Göttingen, Germany.

Nature Structural & Molecular Biology
|February 11, 2025
PubMed
Summary

Promoter-proximal termination of RNA polymerase II (Pol II) plays a key role in regulating gene transcription during human cell transitions. This process influences both gene upregulation and downregulation by affecting initiation frequency and termination rates.

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