Related Experiment Video
Updated: May 28, 2025

The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
Published on: February 21, 2025
Exercise with weight vest plus chicken protein supplementation delayed muscle and bone loss in older female adults
Peeraporn Nithisup1, Apiwan Manimmanakorn1,2, Michael John Hamlin3
1Department of Physiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Purpose:
This study examined the effects of moderate-to-heavy exercise training combined with weighted vest and chicken protein supplementation in older adult females.
Methods:
Fifty-two female participants, 60-79 yearsold, were randomly divided into three groups: control (non-exercise) (CON), exercise with weighted vest (WV), and exercise with weighted vest and protein supplementation (3 g of protein daily; WVP).A ll participants performed brisk walking and strengthening exercises for 50 min/day, three times/week, for 8 weeks. Muscle mass, bone mineral content, T-score, and physical performance were measured.
Results:
The WVP group demonstrated a substantial increase in thoracic spine bone mineral content (8.4 ± 7.7 g, p = 0.001), and total body lean mass (0.2 ± 1.0 kg) compared with that in the other two groups. The CON and WV groups showed a decrease in thoracic spine bone mineral content (CON= -1.8 ± 1.8, WV= -3.9 ± 0.1 g) and total body lean mass (CON= -0.7 ± 0.9, WV= -0.8 ± 0.9 kg) compared with those in the WVP group. The WVP and WV groups had increased T-score (WVP= 0.01 ± 0.16, WV= 0.02 ± 0.18) when compared with that of the CON group (-0.19 ± 0.12). Both the WV and WVP groups displayed improved physical performance compared with that of the CON group.
Conclusion:
Combined exercise with either a weighted vest or protein supplementation proved to be effective in protecting against trunk bone and muscle mass loss, and improving physical fitness in older female adults.
Related Concept Videos
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Exercise and Muscle Performance
Endurance exercises
Endurance exercises involve running, swimming, or cycling, which require repetitive movements with low force output. When a person engages in endurance exercise, a few noticeable changes occur in their skeletal muscles. For instance, the number of capillaries...
The Effect of Aging on Tissues
Role of Vitamins in Maintaining Bone Health
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...

