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The ZNF717-rs2918520 genotype contributes to COVID-19 severity: a Taiwanese cohort study

Yang-Hsiang Lin1, Jen Yu2, Yu-Chuan Teng3

  • 1Liver Research Center, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan.

BMC Infectious Diseases
|February 11, 2025
PubMed

Insights

A novel single nucleotide polymorphism (SNP), ZNF717-rs2918520, was identified in Taiwanese COVID-19 patients. The GG genotype of this SNP is significantly associated with severe COVID-19 symptoms, potentially serving as a severity predictor.

Area of Science:

  • Genetics and genomics
  • Infectious diseases
  • Clinical diagnostics

Background:

  • Coronavirus disease 2019 (COVID-19) poses a global health challenge, particularly severe respiratory failure.
  • Single nucleotide polymorphisms (SNPs) are crucial genetic markers for disease prediction and prognosis.
  • Understanding genetic predispositions is vital for managing COVID-19 severity.

Purpose of the Study:

  • To investigate the clinical associations of SNPs with mild and severe COVID-19 symptoms in the Taiwanese population.
  • To identify potential genetic predictors for COVID-19 severity.

Main Methods:

  • Two independent cohorts of SARS-CoV-2 infected patients were enrolled (n=39 and n=71).
  • Clinical data and genetic information were analyzed using whole exome sequencing, polymerase chain reaction, and Sanger sequencing.
  • Associations between clinical parameters and SNP genotypes with COVID-19 severity were evaluated.

Main Results:

  • Clinical factors like age, liver enzymes, and inflammatory markers correlated with COVID-19 severity.
  • A novel SNP, ZNF717-rs2918520, was identified.
  • The GG genotype of ZNF717-rs2918520 showed a significant association with severe COVID-19 symptoms.

Conclusions:

  • The ZNF717-rs2918520 GG genotype may serve as a valuable predictor for COVID-19 severity in Taiwan.
  • This finding contributes to personalized medicine approaches for managing COVID-19.
Abstract

Keywords:
COVID-19PredictorSNPSeverityZNF717-rs2918520

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