Related Experiment Video
Updated: May 28, 2025

Primer Extension Capture: Targeted Sequence Retrieval from Heavily Degraded DNA Sources
Published on: September 3, 2009
PANE: fast and reliable ancestral reconstruction on ancient genotype data with non-negative least square and
Luciana de Gennaro1, Ludovica Molinaro2, Alessandro Raveane3
1Department of Biosciences, Biotechnology and Environment, University of Bari, Bari, Italy. luciana.degennaro@uniba.it.
Abstract:
The history of human populations has been strongly shaped by admixture events, contributing to patterns of observed genetic diversity across populations. In this study, we introduce the Principal component Ancestry proportions using NNLS Estimation (PANE) method that leverages principal component analysis and non-negative least squares to assess the ancestral compositions of admixed individuals given a large set of populations. Our results show its ability to reliably estimate ancestry across several scenarios, even those with a significant proportion of missing genotypes, in a fraction of the time required when using other tools.
Related Concept Videos
Evolutionary Relationships through Genome Comparisons
Gene Evolution - Fast or Slow?
In contrast, regions which code...
Genetic Drift
Pedigree Analysis
Genetic Variation
Genes exist in different versions called alleles,...
Hardy-Weinberg Principle

