Related Experiment Video
Updated: May 28, 2025
Contact Hypersensitivity as a Murine Model of Allergic Contact Dermatitis
Published on: September 26, 2022
Moisturizer induced contact anaphylaxis
Bronte Jeffrey1,2, Logan Gardner3,4, Michelle Le5
1Department of Clinical Immunology, Westmead Hospital, Sydney, Australia. b.jeffrey@unsw.edu.au.
Background:
Contact allergens typically trigger localised reactions, but systemic Type I hypersensitivity from skin contact reactions are rare.
Case Presentation:
We present the case of a 69-year-old non-atopic male who developed anaphylaxis following the application of moisturizer to an area of chemical burns. Skin testing showed a strong positive result to moisturizer. Whilst not all ingredients were available for testing, phenoxyethanol was thought to be the likely culprit agent based on literature review and a weakly positive skin test result.
Conclusion:
Products such as moisturizers can rarely trigger anaphylaxis, especially when applied to damaged skin which may favor systemic absorption. This case highlights the need for careful consideration of cosmetic application when discerning culprit allergens.
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