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Moisturizer induced contact anaphylaxis.

Bronte Jeffrey1,2, Logan Gardner3,4, Michelle Le5

  • 1Department of Clinical Immunology, Westmead Hospital, Sydney, Australia. b.jeffrey@unsw.edu.au.

Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology
|February 11, 2025
PubMed
Summary
This summary is machine-generated.

Systemic allergic reactions, like anaphylaxis, from skin contact with moisturizers are rare but possible, especially on damaged skin. Phenoxyethanol in a moisturizer was identified as a likely cause in one case.

Keywords:
AllergyAnaphylaxisContactHypersensitivityUrticaria

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Area of Science:

  • Dermatology
  • Allergology
  • Toxicology

Background:

  • Contact allergens usually cause localized skin reactions.
  • Systemic Type I hypersensitivity reactions from dermal exposure are uncommon.
  • Damaged skin may increase the risk of systemic absorption of topical agents.

Purpose of the Study:

  • To report a rare case of anaphylaxis.
  • To identify the causative agent in a moisturizer-induced hypersensitivity reaction.
  • To emphasize the importance of considering cosmetic products in allergen diagnosis.

Main Methods:

  • Case report of a 69-year-old male.
  • Clinical presentation of anaphylaxis post-moisturizer application on chemical burns.
  • Skin testing for suspected allergens.
  • Literature review to identify potential culprit ingredients.

Main Results:

  • The patient experienced anaphylaxis after applying moisturizer to chemical burns.
  • Skin testing revealed a strong positive reaction to the moisturizer.
  • Phenoxyethanol was identified as the probable allergen, supported by literature and a weak positive skin test.

Conclusions:

  • Moisturizers can rarely induce anaphylaxis, particularly when applied to compromised skin.
  • Systemic absorption through damaged skin is a potential mechanism.
  • Clinicians should consider topical cosmetic products as potential triggers for severe allergic reactions.