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Extracellular Vesicle-Based Antitumor Nanomedicines

Mingfeng Li1, Yanfei Liu2, Fei Liu3

  • 1Department of Pharmaceutics, Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, 410013, P. R. China.

Advanced Healthcare Materials
|February 12, 2025
PubMed

Insights

Extracellular vesicles (EVs) show promise as nanomedicines for cancer therapy. This review details EV extraction, drug loading, and engineering for enhanced antitumor treatments and clinical translation.

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Extracellular vesicles (EVs) are natural nanocarriers with therapeutic potential.
  • Existing reviews lack comprehensive coverage of EV-based nanomedicines for cancer therapy.

Purpose of the Study:

  • To review the potential of EVs as antitumor nanomedicines.
  • To systematically examine methods for EV extraction, drug loading, and engineering.
  • To discuss clinical translation challenges and opportunities.

Main Methods:

  • Systematic examination of EV extraction techniques.
  • Assessment of various drug-loading strategies for EVs.
  • Analysis of engineering modifications for enhanced therapeutic efficacy.
  • Review of clinical translation hurdles and future prospects.

Main Results:

  • EVs offer excellent stability and biocompatibility for drug delivery.
  • Multiple methods exist for EV extraction, drug loading, and modification, each with specific strengths and limitations.
  • Key strategies for developing EV-based antitumor therapies are identified.

Conclusions:

  • EVs hold significant promise as a platform for developing novel antitumor nanomedicines.
  • Further interdisciplinary research is needed to overcome challenges in clinical translation.
  • Robust EV-based therapeutic platforms can lead to personalized cancer treatments.
Keywords:
antitumor immunityextracellular vesiclestargeted delivery systemstumor microenvironmenttumor vaccines

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